• The Iceman’s Gut Microbes Cometh

The Iceman’s Gut Microbes Cometh

Analysis of microbes from the gut of the Iceman—a 5300-year-old Copper Age European glacial mummy—provides insights into not only his health status right before he was murdered, but migration patterns of humans and their microbiota. Helicobacter pylori, one of the most prevalent human pathogens, is globally dispersed but has a

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In Vitro Stomach?

Researchers have developed an advanced, long-term, 3-dimensional organoid culture system for primary, untransformed human gastric epithelium. The system, described in the January issue of Gastroenterology, provides evidence for the presence of stem cells in adult human gastric tissue and can be used to study changes that occur in the gastric epithelium during

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Which Therapy for Helicobacter pylori Infection?

A combination of esomeprazole and 3 antimicrobial agents is less expensive and complex, and equally or more effective, than sequential regimens for eradication of  Helicobacter pylori infection, according to the July issue of Gastroenterology. H pylori infection causes stomach cancer in 20% of infected subjects, so it is important to eliminate. Although

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Could Bone Marrow Cells Contribute to Stomach Cancer?

H pylori recruit bone marrow-derived cells to the gastric mucosa that contribute to tumor development, according to the February issue of Gastroenterology. H pylori infection promotes gastric carcinogenesis through many mechanisms, such as causing inflammation and producing virulence factors that alter gastric cell activity. Over time, these lead to metaplasia, dysplasia,

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H Pylori—Are They Gone Yet?

Helicobacter pylori infection can be treated with proton pump inhibitors (PPIs) and antibiotics, but physicians need ways to determine if the bacteria are completely eradicated months later. In the May issue of Clinical Gastroenterology and Hepatology, Luigi Gatta et al. describe a simple blood test that can detect H pylori

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