DDW 2016: Stem Cells Help Heal Perianal Fistulas, Increasing Rates of Colorectal Cancer in Younger Individuals, and Agents Effective Against HCV Genotypes 1–6

Researchers reported important findings on a variety of gastrointestinal and hepatic disorders at Digestive Disease Week in San Diego. – A small, phase 1 study reported that a bioprosthesis plug soaked in autologous mesenchymal stem cells helped heal refractory perianal fistulas that commonly occur in patients with Crohn’s disease. Amy

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  • Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3) is associated with baseline level of fibrosis and its progression, but not development of hepatocellular carcinoma (HCC), in patients with hepatitis C virus (HCV) infection, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Most

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Hepatitis C Epidemic, Associated with Intravenous Drug Use, in Appalachian States

An increase in the abuse of injectable drugs has caused rates of hepatitis C virus (HCV) infection to more than triple in 4 Appalachian states, according to a report from the Centers for Disease Control and Prevention. The rates were highest among people under age 30 in rural areas of Kentucky, Tennessee,

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  • How Do NS5A Inhibitors Prevent HCV Replication?

How Do NS5A Inhibitors Prevent HCV Replication?

Researchers have uncovered the mechanisms of drugs that inhibit the hepatitis C virus (HCV) non-structural protein 5A (NS5A), described in the August issue of Gastroenterology. In a quantitative analysis of the kinetics of NS5A inhibitors, David R. McGivern et al.  show that these agents rapidly inhibit intracellular assembly of virions and

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