• How to Get Rid of H pylori Infection—And do we Need to?

How to Get Rid of H pylori Infection—And do we Need to?

Helicobacter pylori infection increases risk of gastric cancer, by inducing inflammation and genetic instability in the gastric mucosa. However, it is not clear how best to clear the infection, or even whether H pylori can provide some health benefits. In a Review article in the April issue of Gastroenterology, David Y. Graham discusses the mechanisms H pylori–induced carcinogenesis and

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  • Author Q&A Series: H pylori-associated Gastric Cancer

Author Q&A Series: H pylori-associated Gastric Cancer

Gastric tumors and tissues from humans and mice accumulate somatic mutations in various genes in the gastric mucosa upon Helicobacter pylori infection, researchers report in the August issue of Gastroenterology. In the study, Takahiro Shimizu et al. show that increased cytidine deaminase activity in these tissues promotes the accumulation of these mutations and might

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  • Does Getting Rid of H pylori Stop Gastric Cancer’s Return?

Does Getting Rid of H pylori Stop Gastric Cancer’s Return?

Eradication of Helicobacter pylori after endoscopic resection of gastric lesions doesn’t prevent later development of new stomach tumors, researchers report in the May issue of Clinical Gastroenterology and Hepatology. H pylori infection can lead to gastric atrophy, intestinal metaplasia, and dysplasia or cancer—specifically non-cardia gastric cancer. It does so by inducing inflammation

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