• A New Pathway for Transmitting HBV DNA?

A New Pathway for Transmitting HBV DNA?

Extracellular vesicles carry HBV DNA as cargo that can be transmitted to other hepatocytes, researchers report in the March issue of Cellular and Molecular Gastroenterology and Hepatology. Their findings identify an antibody-neutralization–resistant route of HBV infection. Approximately 350 million people are chronically infected by HBV worldwide, and some of these

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Hepatic Gene Therapy Technique Developed

Researchers have developed a technique for selective expansion of genetically modified hepatocytes, resulting in expression of high levels of transgenes in livers of mice. Sean Nygaard et al (Oregon Health and Science University) describe their system for in vivo selection and expansion of genetically modified hepatocytes in the June 8

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  • What Controls Liver Size?

What Controls Liver Size?

Most people know that liver can regenerate, but how does it know when to stop growing? Liver size is, in part, regulated by the size of the circulating bile acid pool, controlled by fibroblast growth factor 19 (FGF19), researchers show in the September issue of Gastroenterology. The mammalian liver can

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Cheap Allergy Drug Prevents HCV Infection of Hepatocytes

An over-the-counter allergy drug may be repurposed to treat patients with hepatitis C, researchers show. Chlorcyclizine, which costs about $0.50 a tablet, could offer a low-cost alternative or addition to treatment for patients with hepatitis C virus (HCV) infection. Direct-acting antiviral therapies can cure hepatitis C, but their high cost—which

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  • What is the Best Way to Care for Patients with Alcoholic Hepatitis?

What is the Best Way to Care for Patients with Alcoholic Hepatitis?

Although alcohol-related liver disease is the 8th most common cause of mortality in the US and the 2nd leading cause of mortality among all gastrointestinal diseases, there are few therapeutic options for patients or resources to support identification of new therapies. However, treatment approaches are being developed; a review in

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