• Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • What are the Roles for Chemokines in Liver Disease?

What are the Roles for Chemokines in Liver Disease?

Sustained hepatic inflammation contributes to the progression of chronic liver diseases such as hepatitis C and non-alcoholic steatohepatitis. In the September issue of Gastroenterology, Fabio Marra and Frank Tacke review the roles of chemokines in liver inflammation and disease progression. In the liver, chemokines regulate the migration and activities of hepatocytes, Kupffer

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