• Are Patients With PSC and Colitis More likely to Have Subclinical Inflammation?

Are Patients With PSC and Colitis More likely to Have Subclinical Inflammation?

Patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) in remission are significantly more likely to have inflammation of the right colon, based on endoscopic and histologic markers, than patients with UC without PSC, researchers report in the January issue of Clinical Gastroenterology and Hepatology. These findings provide insight into cause

Read more
  • Does Immunomodulator Therapy for IBD During Pregnancy Affect Newborn Response to Vaccines?

Does Immunomodulator Therapy for IBD During Pregnancy Affect Newborn Response to Vaccines?

Rates of adequate serologic response to Haemophilus influenzae B (HiB) and tetanus vaccines are similar among infants born to women with inflammatory bowel diseases (IBD) treated with immunomodulator or biologic agents compared to women who did not receive these immunosuppressive drugs during pregnancy, researchers report in the January issue of Clinical Gastroenterology

Read more
  • Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Detection of flat low-grade dysplasia (fLGD) and aneuploidy in colon tissues increases risk for high-grade dysplaisa (HGD) or colorectal cancer (CRC) more than 5-fold in patients with inflammatory bowel disease (IBD), researchers report in the December issue of Gastroenterology. Aneuploidy was also detected in almost all cases of flat HGD (fHGD) IBD is a risk

Read more
  • 3-D Imaging of T-cell Localization in Inflamed Colon Tissues

3-D Imaging of T-cell Localization in Inflamed Colon Tissues

Light sheet fluorescence microscopy (LSFM) provides accurate 3-dimensional images of inflammed intestine of mice with colitis, researchers show in a Gastroenterology in Motion article and video in the October issue of Gastroenterology. The authors demonstrate use of the technology to analyze migration of human T cells in colons of mice with colitis. Improved techniques are

Read more
  • Could the Microbiota Link Metabolic Syndrome With Inflammation?

Could the Microbiota Link Metabolic Syndrome With Inflammation?

Bacterial encroachment—shrinking of the bug-free zone adjacent to the colonic epithelium—is a feature of metabolic syndrome, researchers report in the September issue of Cellular and Molecular Gastroenterology and Hepatology. The findings could explain the relationship between diabetes and inflammation. Mucoid structures that coat the epithelium keep the intestinal microbiota at

Read more
  • Does Consumption of Certain Fatty Acids Increase Risk of Ulcerative Colitis Flares?

Does Consumption of Certain Fatty Acids Increase Risk of Ulcerative Colitis Flares?

Diets with high levels of fatty acids such as myristic acid (found in palm oil, coconut oil, and dairy fats) increased risk of flare in patients with ulcerative colitis (UC), researchers report in the September issue of Clinical Gastroenterology and Hepatology. Their findings, from a prospective study of more than 400 patients

Read more
  • Does Asthma Increase Risk for Inflammatory Bowel Diseases?

Does Asthma Increase Risk for Inflammatory Bowel Diseases?

A population-based case–control study published in the September issue of Clinical Gastroenterology and Hepatology associates asthma with later development of Crohn’s disease (CD) and with ulcerative colitis (UC). Although the etiology of asthma and inflammatory bowel diseases (IBD) are not well understood, they both involve complex interactions among genetic and environmental factors and the

Read more
  • Is Endoscopic Balloon Dilation Better Than Surgery for Patients With Crohn’s Disease-related Strictures?

Is Endoscopic Balloon Dilation Better Than Surgery for Patients With Crohn’s Disease-related Strictures?

In patients with Crohn’s disease (CD), surgical treatment of ileocolonic anastomosis strictures reduces risk of further surgery compared with endoscopic balloon dilation (EBD), researchers report in the August issue of Clinical Gastroenterology and Hepatology. However, endoscopic balloon dilation (EBD) delays time until need for a second surgery; EBD should be therefore attempted first

Read more
  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

Read more
  • Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Serum levels of vitamin D of 35 ng/mL or less in patients with ulcerative colitis (UC) in clinical remission are associated with disease relapse, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Increasing patients’ levels of vitamin D might reduce their risk for UC relapse. Vitamin D

Read more