What Happens to Infants Whose Mothers Took Anti-TNF Agents During Pregnancy?

Anti-tumor necrosis factor (TNF) agents can be detected in infants born to mothers with inflammatory bowel diseases (IBD) who took the drugs during pregnancy, researchers report in the July issue of Gastroenterology. Infliximab is cleared more slowly than adalimumab from infants. However, measureable levels in infants do not seem to be

Read more

Pyoderma Gangrenosum in Fingers of Patient With Crohn’s Disease

In the July issue of Clinical Gastroenterology and Hepatology, researchers describe a patient with Crohn’s disease who developed pyoderma gangrenosum in an unusual location. Faisal Inayat and Abu Hurairah describe a 40-year-old woman who came into the hospital with bilateral, mild, localized pain and discoloration of the fingernails for 10 days (see picture).

Read more
  • Can we Identify People With IBD Before Symptoms Develop?

Can we Identify People With IBD Before Symptoms Develop?

People have high plasma levels of interleukin-6 (IL6) and c-reactive protein years before they are diagnosed with inflammatory bowel diseases (IBD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. These markers of systemic inflammation could be features of early-stage disease used to identify patients at risk. Crohn’s

Read more

DDW 2016: Stem Cells Help Heal Perianal Fistulas, Increasing Rates of Colorectal Cancer in Younger Individuals, and Agents Effective Against HCV Genotypes 1–6

Researchers reported important findings on a variety of gastrointestinal and hepatic disorders at Digestive Disease Week in San Diego. – A small, phase 1 study reported that a bioprosthesis plug soaked in autologous mesenchymal stem cells helped heal refractory perianal fistulas that commonly occur in patients with Crohn’s disease. Amy

Read more

Does IBD Increase Risk for Oral Cancer?

Patients with inflammatory bowel diseases (IBD) have an increased risk of oral cancers—especially tongue cancer—researchers report in the March issue of Clinical Gastroenterology and Hepatology. Women are at higher risk than men. Oral cancers develop in the mucosal surfaces of the lips, floor of mouth, tongue, buccal mucosa, lower and

Read more

Should Patients with Crohn’s Disease Continue Receiving Immunomodulators When Starting Anti-TNF Therapy?

Continued use of immunomodulator therapy in patients with Crohn’s disease receiving anti-tumor necrosis factor (TNF) therapy is no more effective than anti-TNF monotherapy in inducing or maintaining response or remission, researchers show. The meta-analysis of randomized controlled trials is published in the December issue of Clinical Gastroenterology and Hepatology. There is debate

Read more
  • What Loci Determine Susceptibility to IBD in African Americans?

What Loci Determine Susceptibility to IBD in African Americans?

Although many of the same genetic variants determine susceptibility to inflammatory bowel diseases (IBD) in Caucasians and African Americans, researchers report the identification of variants and loci not previously associated with IBD in African American populations. Analyses of these could provide insight into the pathogenesis of IBD, researchers state in

Read more
  • This is Your Brain on Anti-TNF Therapy

This is Your Brain on Anti-TNF Therapy

Anti-tumor necrosis factor (anti-TNF) agents rapidly reduce pain perception in brains of patients with Crohn’s disease, researchers show in the October issue of Gastroenterology. This observation could explain how clinical disease activity is often reduced long before signs of mucosal healing. Patients with Crohn’s disease treated with anti-TNF agents often report reductions in abdominal pain

Read more
  • Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

A special issue of Gastroenterology features 14 articles discussing the genetic factors that contribute to a range of gastrointestinal (GI),  hepatobiliary, and pancreatic diseases, and how this information can be used in diagnosis and treatment of patients. An introduction to the special issue explains the value of associating diseases with specific genetic variants, which can help

Read more
  • Anemia—a Real Problem for Patients With IBD

Anemia—a Real Problem for Patients With IBD

Persistent or recurrent anemia is associated with severe and disabling inflammatory bowel disease (IBD), researchers report in the October issue of Clinical Gastroenterology and Hepatology. Persistent or recurrent anemia could be used as a marker of severe disease and to identify patients who require aggressive management. Anemia is a well-recognized but underestimated problem

Read more