Can Patients With Crohn’s Disease Ever Stop Taking Infliximab?

Half of patients with Crohn’s disease treated with infliximab experience a relapse within the first year after they stop taking the drug, according to a study published in the January issue of Gastroenterology. Drugs such as infliximab inhibit the inflammatory cytokine tumor necrosis factor (TNF) and are effective in reducing

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What Does the Appendix Do, Anyway?

The appendix protects against recurrent infection by Clostridium difficile (C difficile) and possibly other pathogenic bacteria, according to a study published in the December issue of Clinical Gastroenterology and Hepatology. Although the human appendix is considered to be expendable, it contains gut-associated lymphoid tissue (GALT), which processes antigen and regulates

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High Rate of Complications from Colectomy for Ulcerative Colitis

Twenty-seven percent of patients who are treated for ulcerative colitis by colectomy experience postoperative complications, according to a study in the November issue of Clinical Gastroenterology and Hepatology. Most patients with ulcerative colitis are successfully treated with medication, yet some have severe colitis attacks that can be life threatening. Approximately

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Certolizumab and Remission in Some Patients With Crohn’s Disease

The drug certolizumab pegol induces remission in patients with Crohn’s disease who have high baseline levels of inflammation, according to William Sandborn et al. in the August issue of Clinical Gastroenterology and Hepatology. Patients with moderate to severe Crohn’s disease that do not respond conventional therapy are often treated with

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Tracking Crohn’s Therapy

Measuring blood levels of C-reactive protein (CRP), a marker of inflammation, is a good way to monitor recovery from Crohn’s disease (CD) in patients being treated with infliximab, according to Matthias Jürgens et al. in the May issue of Clinical Gastroenterology and Hepatology. CRP is a protein released into the blood

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Curbing Crohn’s for the Long Term?

Most people with Crohn’s disease receive surgery, yet the disease comes back a short time later. A study in the July issue of Clinical Gastroenterology and Hepatology reports that giving patients low doses of infliximab immediately after surgery prevents disease recurrence over long time periods. Dario Sorrentino et al. began

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