• Genetic Variants Associated with IBD Alter Immune Regulatory Signals from Beneficial Microbes

Genetic Variants Associated with IBD Alter Immune Regulatory Signals from Beneficial Microbes

Polymorphisms in susceptibility genes appear to promote development of inflammatory bowel diseases (IBD) by altering the abilities of immune cells to sense protective signals from the microbiome, researchers report. These findings help fill the missing link between genetic risk variants for IBD and dysbiosis of the intestinal microbiome. More than

Read more
  • Restoring Immune Regulation to Patients With Alcoholic Hepatitis

Restoring Immune Regulation to Patients With Alcoholic Hepatitis

Patients with alcoholic hepatitis have dysfunctional T-cell and natural killer cell responses that lead to overwhelming bacterial infections. Researchers report in the March issue of Gastroenterology that the immune impairment is mediated by endotoxin-induced over-expression of proteins called programmed cell death 1 (PD1) and mucin domain–containing protein 3 (TIM3), which suppress the immune

Read more
  • Does Coffee Affect Development of Cholestatic Liver Disorders?

Does Coffee Affect Development of Cholestatic Liver Disorders?

Lower levels of coffee consumption are associated with primary sclerosing cholangitis (PSC), but not primary biliary cirrhosis (PBC), researchers report in the September issue of Clinical Gastroenterology and Hepatology. Coffee is considered to be a medically beneficial beverage—consumption has been associated with reductions in metabolic syndrome, cardiovascular disease, and weight

Read more
  • Special Issue: The Gut Microbiome

Special Issue: The Gut Microbiome

Gastroenterology is proud to present a special issue devoted to ‘The Gut Microbiome in Health and Disease’. The human body contains over 10 times more microbial cells than human cells. This microbiome (the commensal, symbiotic, and pathogenic microorganisms that share our body space) maintains the health and function of many

Read more

Causes and Treatment of Very-Early Onset IBD

Many infants with inflammatory bowel disease (IBD) have genetic defects that disrupt IL-10 signaling, according to the August issue of Gastroenterology. However, these children can be successfully treated by allogeneic hematopoietic stem cell transplantation, researchers report. IBD develops mostly in adolescents and young adults, but can occur in very young

Read more

What Does the Appendix Do, Anyway?

The appendix protects against recurrent infection by Clostridium difficile (C difficile) and possibly other pathogenic bacteria, according to a study published in the December issue of Clinical Gastroenterology and Hepatology. Although the human appendix is considered to be expendable, it contains gut-associated lymphoid tissue (GALT), which processes antigen and regulates

Read more