• Can we Identify People With IBD Before Symptoms Develop?

Can we Identify People With IBD Before Symptoms Develop?

People have high plasma levels of interleukin-6 (IL6) and c-reactive protein years before they are diagnosed with inflammatory bowel diseases (IBD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. These markers of systemic inflammation could be features of early-stage disease used to identify patients at risk. Crohn’s

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  • Genetic Variants Associated with IBD Alter Immune Regulatory Signals from Beneficial Microbes

Genetic Variants Associated with IBD Alter Immune Regulatory Signals from Beneficial Microbes

Polymorphisms in susceptibility genes appear to promote development of inflammatory bowel diseases (IBD) by altering the abilities of immune cells to sense protective signals from the microbiome, researchers report. These findings help fill the missing link between genetic risk variants for IBD and dysbiosis of the intestinal microbiome. More than

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  • What Happens to Patients With Markers of Celiac Disease but no Symptoms?

What Happens to Patients With Markers of Celiac Disease but no Symptoms?

A 3-year study of adults with potential celiac disease found most to have symptoms, and that these adults improve after gluten withdrawal, as reported in the May issue of Clinical Gastroenterology and Hepatology. The study also shows that patients without symptoms should not go on gluten-free diets, because they are unlikely

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  • Do NSAIDs Prevent PEP?

Do NSAIDs Prevent PEP?

Rectal indomethacin does not prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), researchers report from a randomized controlled study published in the April issue of Gastroenterology. These findings contradict more than a decade of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of post-ERCP pancreatitis (PEP). Acute pancreatitis is the

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  • Gut Microbes Affect Extent of Brain Injury After Stroke

Gut Microbes Affect Extent of Brain Injury After Stroke

Altering the intestinal microbiota of mice can reduce the extent of brain damage after a stroke, researchers found. These findings provide a previously unrecognized link between the intestine and the brain. The composition of the intestinal microbiome affects development of the immune system and metabolic processes, and is altered in

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  • Do Symptoms of Eosinophilic Esophagitis Indicate Disease Activity?

Do Symptoms of Eosinophilic Esophagitis Indicate Disease Activity?

Lack of symptoms of eosinophilic esophagitis (EoE) does not necessarily mean a lack of disease activity, researchers report in the March issue of Gastroenterology. They found only a moderate association between symptom scores and endoscopic or histologic features of remission. EoE is a chronic, immune- or antigen-mediated esophageal disease characterized

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Does IBD Increase Risk for Oral Cancer?

Patients with inflammatory bowel diseases (IBD) have an increased risk of oral cancers—especially tongue cancer—researchers report in the March issue of Clinical Gastroenterology and Hepatology. Women are at higher risk than men. Oral cancers develop in the mucosal surfaces of the lips, floor of mouth, tongue, buccal mucosa, lower and

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  • What is the Best way to Manage Diverticulitis, and how Many People Have it?

What is the Best way to Manage Diverticulitis, and how Many People Have it?

Not all patients with multiple episodes of diverticulitis should undergo preventative surgery, shows a Markov decision model published in the January 2016 issue of Clinical Gastroenterology and Hepatology. Elective surgery after 2 episodes produces fewer quality-adjusted life-years (QALYs) than surgery after 3 episodes or conservative or medical treatments, the model found.

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  • This is Your Brain on Anti-TNF Therapy

This is Your Brain on Anti-TNF Therapy

Anti-tumor necrosis factor (anti-TNF) agents rapidly reduce pain perception in brains of patients with Crohn’s disease, researchers show in the October issue of Gastroenterology. This observation could explain how clinical disease activity is often reduced long before signs of mucosal healing. Patients with Crohn’s disease treated with anti-TNF agents often report reductions in abdominal pain

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  • Anemia—a Real Problem for Patients With IBD

Anemia—a Real Problem for Patients With IBD

Persistent or recurrent anemia is associated with severe and disabling inflammatory bowel disease (IBD), researchers report in the October issue of Clinical Gastroenterology and Hepatology. Persistent or recurrent anemia could be used as a marker of severe disease and to identify patients who require aggressive management. Anemia is a well-recognized but underestimated problem

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