Video: Prick Test to Identify Allergens That Cause Esophageal Sensitization

An esophageal prick test, in which allergens are injected directly into the esophageal mucosa, appears to identify individuals with esophageal sensitization, researchers report in the January issue of Gastroenterology. In patients with eosinophilic esophagitis (EoE), food allergens are believed to induce an inflammatory response that can make swallowing and eating a challenge. Identifying and

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Who Will Develop Pouchitis After Ileal Pouch–Anal Anastomosis?

Serum markers can be used to identify patients with ulcerative colitis most likely to have inflammatory complications after ileal pouch–anal anastomosis (IPAA), according to the May issue of Clinical Gastroenterology and Hepatology. More than 20% of individuals with ulcerative colitis eventually need surgery for this disease. Patients with fulminant or

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An Immune Culprit in IBD?

Patients with Crohn’s disease or ulcerative colitis have reduced levels of an important regulator of the immune response—the receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF)—according to a study by Jonathan Goldstein et al. in the July issue of Gastroenterology. The inflammatory bowel diseases (IBD) ulcerative colitis and Crohn’s disease arise from

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IBD Guardian

Researchers have identified a molecule that protects colon cells from injury in a mouse model of inflammatory bowel disease (IBD). The study, published by Beth McConnell et al. in the February issue of Gastroenterology, reports that Klf5 controls genes that mediate recovery from colonic injury. Klf5 regulates transcription of genes

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