• 6000-Calorie Diet Reveals Mechanisms of Obesity-Linked Insulin Resistance

6000-Calorie Diet Reveals Mechanisms of Obesity-Linked Insulin Resistance

A study in which researchers place healthy individuals on 6000-calorie per day diets has identified biologic changes that take place during the early stages of obesity and could lead to insulin resistance. The study, published in the 9 September issue of Science Translational Medicine, pinpoints oxidative stress as the potential

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A New Drug for Diabetes and Fatty Liver Disease?

Obeticholic acid (OCA)—an agonist of the farnesoid X receptor (FXR)— increases insulin sensitivity and reduces markers of liver inflammation and fibrosis in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), according to a study published in the September issue of Gastroenterology. Type 2 diabetes mellitus and

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Which Patients With Barrett’s Esophagus Will Develop Esophageal Cancer?

Researchers have found markers to identify patients with Barrett’s esophagus (BE) at greatest risk of developing esophageal adenocarcinoma. These are described in the August issue of Clinical Gastroenterology and Hepatology. In patients with BE, part of the normal stratified squamous epithelium of the lower esophagus is replaced with metaplastic columnar

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Does the Western Diet Promote Endotoxemia and Inflammation?

A high-fat diet can cause endotoxemia, which promotes the systemic inflammation and metabolic disorders associated with obesity, according to a human study published in the May issue of Gastroenterology. Chronic endotoxemia (the presence of endotoxins such as lipopolysaccharide in blood) occurs with obesity, yet little is known about the source

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