• An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

Undifferentiated or crypt-like, and differentiated or villus-like, human intestinal enteroids represent distinct points along the crypt–villus axis and can be used to characterize electrolyte transport processes along the small intestine, researchers report in the March issue of Gastroenterology. Studies of their duodenal enteroid model showed that electrogenic Na+/HCO3– cotransporter 1 in the

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  • Review: LGR5 and Intestinal Stem Cells

Review: LGR5 and Intestinal Stem Cells

Since the discovery of LGR5 as a marker of intestinal stem cells, we have learned a great deal about the intestinal crypt stem cell niche. In the August issue of Gastroenterology Bon-Kyoung Koo and Hans Clevers review the discovery of crypt base columnar cells as LGR5+ adult stem cells and

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