• Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

An individualized, food-based diet with similar composition of nutrients to exclusive enteral nutrition (EEN), causes similar changes in the microbiomes of patients with Crohn’s disease (CD), reduces gut inflammation, and is preferred by patients, researchers report in the April issue of Gastroenterology. Non-medical treatments are needed for patients with CD. Diet

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  • Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Diets that promote intestinal inflammation can increase risk of colorectal carcinomas associated with specific bacteria in the microbiome, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Diet-induced intestinal inflammation alters the gut microbiome to contribute to colorectal cancer risk, which might be reduced with dietary changes. Chronic inflammation

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How Does an Antibiotic Reduce Symptoms of IBS?

Rifaximin alters the intestinal microbiota to prevent inflammation and visceral hyperalgesia in stressed rats, according to the February issue of Gastroenterology. These findings could explain the ability of this antibiotic to relieve symptoms of irritable bowel syndrome (IBS) in patients. Rifaximin is a broad-spectrum antibiotic that has been approved by

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  • Cannabis for Crohn’s Disease?

Cannabis for Crohn’s Disease?

Eight weeks of therapy with Δ9-tetrahydrocannabinol (THC)-rich cannabis reduced symptoms in patients with active Crohn’s disease, according to a controlled trial published in the October issue of Clinical Gastroenterology and Hepatology. However, these effects were only temporary. The marijuana plant Cannabis sativa has been used for centuries to treat a

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Causes and Treatment of Very-Early Onset IBD

Many infants with inflammatory bowel disease (IBD) have genetic defects that disrupt IL-10 signaling, according to the August issue of Gastroenterology. However, these children can be successfully treated by allogeneic hematopoietic stem cell transplantation, researchers report. IBD develops mostly in adolescents and young adults, but can occur in very young

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Does the Western Diet Promote Endotoxemia and Inflammation?

A high-fat diet can cause endotoxemia, which promotes the systemic inflammation and metabolic disorders associated with obesity, according to a human study published in the May issue of Gastroenterology. Chronic endotoxemia (the presence of endotoxins such as lipopolysaccharide in blood) occurs with obesity, yet little is known about the source

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Does Celiac Disease Increase the Risk of GI Cancer?

People with celiac disease do not have an increased risk of developing gastrointestinal (GI) cancers, according to a large population-based study from Peter Elfström et al. in the January issue of Clinical Gastroenterology and Hepatology. Celiac disease has been associated with GI cancers in small studies, but there have been

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