• What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

New approaches are needed to generate and maintain stable and mature adult liver cells ex vivo. In the April issue of Gastroenterology, Bart Spee and colleagues review factors that promote hepatocyte differentiation and maturation, and consider criteria for establishing whether cells derived from stem cells are fully mature hepatocytes. They discuss challenges to cell transplantation and

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  • What Happens in the Intestine in Patients With Wilson Disease?

What Happens in the Intestine in Patients With Wilson Disease?

ATP7B regulates vesicular storage of copper and buffers its levels in enterocytes to maintain a range necessary for formation of lipid-transporting vesicles, researchers report in the January issue of Gastroenterology. The authors show that a misbalance of copper and lipid in the intestine could account for gastrointestinal manifestations of Wilson

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  • FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

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  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease
  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A man with sickle cell disease with generalized pain and progressive jaundice originally thought to have cholangiocarcinoma was eventually found to have Rosai-Dorfman disease, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Arian Teymoorian et al describe the case of a 38-year-old black man with a history of

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  • Hepatosplenic Lesions from Cat Scratch Disease

Hepatosplenic Lesions from Cat Scratch Disease

Researchers describe an unusual case of cat scratch disease, with hepatosplenic involvement, in the January 2017 issue of Clinical Gastroenterology and Hepatology. Sean K. Verma et al report on a 28-year-old man with no past medical history presented with fevers, chills, abdominal pain, night sweats, 3 weeks of weight loss,

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  • How Does Inflammation Lead to Anemia?

How Does Inflammation Lead to Anemia?

Researchers report a mechanism by which inflammation contributes to development of anemia in the November issue of Gastroenterology. The process involves increased liver expression of a microRNA that reduces production of erythropoietin in kidney. Strategies to block this miRNA might help prevent anemia in patients with chronic inflammation. Anemia is associated

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  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Mice with defects in intestinal epithelial permeability develop more severe steatohepatitis when placed on a diet high in saturated fat, fructose, and cholesterol (HFCD) than control mice, and colon tissues from patients with non-alcoholic fatty liver disease (NAFLD) have similar defects in intestinal epithelial permeability, researchers report in the October

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Hepatic Gene Therapy Technique Developed

Researchers have developed a technique for selective expansion of genetically modified hepatocytes, resulting in expression of high levels of transgenes in livers of mice. Sean Nygaard et al (Oregon Health and Science University) describe their system for in vivo selection and expansion of genetically modified hepatocytes in the June 8

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  • What can we do with Gastrointestinal Organoids?

What can we do with Gastrointestinal Organoids?

Researchers review the latest discoveries from studies of tissue-derived and pluripotent stem cell–derived intestinal, gastric, esophageal, liver, and pancreatic organoids in the May issue of Gastroenterology. Studies of organoids have provided valuable information about GI development, tissue homeostasis, and disease and might be used to develop personalized medicines. In vitro organoid cultures are

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