• Is it Cost Effective to Transplant HCV-positive Livers Into HCV-negative Patients?

Is it Cost Effective to Transplant HCV-positive Livers Into HCV-negative Patients?

A Markov-based mathematical model estimates that transplanting hepatitis C virus (HCV)-positive livers into HCV-negative patients who have received direct-acting antiviral (DAA) agents would be cost effective and improve outcomes, researchers report in the March issue of Clinical Gastroenterology and Hepatology. There has been a steady increase in the number of

Read more
  • REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

CRISPR-Cas9 technology can be used to engineer organoids for studies of gastrointestinal development and disease pathogenesis. In the February issue of Gastroenterology, Masayuki Fujii et al review derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 has advanced studies of the digestive system. CRISPR-Cas9 genome editing technology allows researchers to

Read more
  • 500 Posts by the AGA Journals Blog

500 Posts by the AGA Journals Blog

This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon

Read more
  • What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

What are the Challenges to In Vitro Maturation of Hepatic Stem Cells?

New approaches are needed to generate and maintain stable and mature adult liver cells ex vivo. In the April issue of Gastroenterology, Bart Spee and colleagues review factors that promote hepatocyte differentiation and maturation, and consider criteria for establishing whether cells derived from stem cells are fully mature hepatocytes. They discuss challenges to cell transplantation and

Read more
  • What Happens in the Intestine in Patients With Wilson Disease?

What Happens in the Intestine in Patients With Wilson Disease?

ATP7B regulates vesicular storage of copper and buffers its levels in enterocytes to maintain a range necessary for formation of lipid-transporting vesicles, researchers report in the January issue of Gastroenterology. The authors show that a misbalance of copper and lipid in the intestine could account for gastrointestinal manifestations of Wilson

Read more
  • FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

Read more
  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease
  • A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A Patient Thought to Have Cholangiocarcinoma Found to Have Rosai-Dorfman Disease

A man with sickle cell disease with generalized pain and progressive jaundice originally thought to have cholangiocarcinoma was eventually found to have Rosai-Dorfman disease, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Arian Teymoorian et al describe the case of a 38-year-old black man with a history of

Read more
  • Hepatosplenic Lesions from Cat Scratch Disease

Hepatosplenic Lesions from Cat Scratch Disease

Researchers describe an unusual case of cat scratch disease, with hepatosplenic involvement, in the January 2017 issue of Clinical Gastroenterology and Hepatology. Sean K. Verma et al report on a 28-year-old man with no past medical history presented with fevers, chills, abdominal pain, night sweats, 3 weeks of weight loss,

Read more
  • How Does Inflammation Lead to Anemia?

How Does Inflammation Lead to Anemia?

Researchers report a mechanism by which inflammation contributes to development of anemia in the November issue of Gastroenterology. The process involves increased liver expression of a microRNA that reduces production of erythropoietin in kidney. Strategies to block this miRNA might help prevent anemia in patients with chronic inflammation. Anemia is associated

Read more
  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

Read more