• How Does Alpha-1 Antitrypsin Deficiency Affect the Liver?

How Does Alpha-1 Antitrypsin Deficiency Affect the Liver?

Adults with a severe form of alpha-1 antitrypsin deficiency (AATD) caused by the Pi*Z mutation, and mice with the same genetic alteration, can have liver steatosis and impaired lipid secretion, researchers report in the September issue of Gastroenterology. The research team found factors associated with significant liver fibrosis in patients

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Which Patients with Cystic Fibrosis are at Greatest Risk for Pancreatitis?

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause well-known lung defects, but in the January issue of Gastroenterology, Chee Y. Ooi et al. describe specific CFTR genotypes that increase risk for pancreatitis. Most patients with cystic fibrosis that carry mutations that severely disrupt CFTR function have a pancreatic

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