• 3-D Imaging of T-cell Localization in Inflamed Colon Tissues

3-D Imaging of T-cell Localization in Inflamed Colon Tissues

Light sheet fluorescence microscopy (LSFM) provides accurate 3-dimensional images of inflammed intestine of mice with colitis, researchers show in a Gastroenterology in Motion article and video in the October issue of Gastroenterology. The authors demonstrate use of the technology to analyze migration of human T cells in colons of mice with colitis. Improved techniques are

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  • Which Patients Are at Greatest Risk From Mushroom Poisoning?

Which Patients Are at Greatest Risk From Mushroom Poisoning?

Almost 20% of patients with liver damage from mushroom (Amanita) poisoning and peak levels of total bilirubin greater than 2 mg/dL require liver transplantation or die, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The authors show that peak level of aspartate aminotransferase (AST) below 4000 IU/L identifies

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  • Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Serum levels of vitamin D of 35 ng/mL or less in patients with ulcerative colitis (UC) in clinical remission are associated with disease relapse, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Increasing patients’ levels of vitamin D might reduce their risk for UC relapse. Vitamin D

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  • Can Histologic Features Identify Patients with GERD?

Can Histologic Features Identify Patients with GERD?

Total epithelial thickness is a robust histologic marker that can be used in detection of gastroesophageal reflux disease (GERD), researchers report in the November issue of Clinical Gastroenterology and Hepatology. GERD can be a challenge to diagnose because its symptoms overlap with those of other disorders. Endoscopy and esophageal pH

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  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • Do Symptoms of Eosinophilic Esophagitis Indicate Disease Activity?

Do Symptoms of Eosinophilic Esophagitis Indicate Disease Activity?

Lack of symptoms of eosinophilic esophagitis (EoE) does not necessarily mean a lack of disease activity, researchers report in the March issue of Gastroenterology. They found only a moderate association between symptom scores and endoscopic or histologic features of remission. EoE is a chronic, immune- or antigen-mediated esophageal disease characterized

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  • Biomarker of Early-stage Aggressive Colon Cancer

Biomarker of Early-stage Aggressive Colon Cancer

Lack of the biomarker CDX2 identifies a subgroup of patients with high-risk stage II colon cancer who appeared to benefit from adjuvant chemotherapy. These patients are usually treated with surgery alone. The findings come from a study published online January 21 in the New England Journal of Medicine. Piero Dalerba

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  • Finding Circulating Tumor Cells in Patients With Pancreaticobiliary Cancers

Finding Circulating Tumor Cells in Patients With Pancreaticobiliary Cancers

Circulating tumor cells (CTCs) can be isolated from portal venous blood collected during endoscopic ultrasound (EUS) of patients with pancreaticobiliary cancers, researchers report in the December issue of Gastroenterology. CTCs isolated from peripheral blood of patients with metastatic breast, colorectal, or prostate cancer can be analyzed to predict patient survival. However, blood samples from

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  • Cancer Cells in Circulation

Cancer Cells in Circulation

Pancreatic cancer cells can be detected in patients’ circulation before tumors are discovered, researchers report in the March issue of Gastroenterology. Cancer cells have long been believed to acquire metastatic potential after large primary tumors are established. However, many patients undergoing pancreatectomy for chronic pancreatitis are found to have disseminated pancreatic

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A New Way to Detect Pancreatic Tumors?

Researchers have developed an ultrasound technique to image pancreatic tumors in mice, described in the October issue of Gastroenterology. This approach might useful in early detection of pancreatic ductal adenocarcinoma (PDAC). PDAC is the fourth leading cause of cancer death in the United States. It is usually diagnosed at an

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