• Has MELD-Na Improved Outcomes of Patients on the Liver Transplant Waitlist?

Has MELD-Na Improved Outcomes of Patients on the Liver Transplant Waitlist?

Liver allocation based on model for end-stage liver disease-sodium (MELD-Na) score improved waitlist outcomes and provided significant benefit to patients with hyponatremia, researchers report in the November issue of Gastroenterology. However, there are discrepancies in transplantation survival benefit, so current rules for liver allocation might require revision, the authors state. The

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  • Does Colony Stimulating Factor Increase Survival of Patients with Alcoholic Hepatitis?

Does Colony Stimulating Factor Increase Survival of Patients with Alcoholic Hepatitis?

In a pilot study from the October issue of Clinical Gastroenterology and Hepatology, colony stimulating factor 3 (CSF3, also called GCSF) improved liver function and increased survival times in patients with severe alcohol-associated hepatitis (AH), compared with standard therapy. Addition of N-acetyl cysteine (NAC) to GCSF did not improve patient outcomes. Patients

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  • What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

What are the Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis?

Vitamin K antagonists (VKAs) increase risk of minor bleeding in patients with cirrhosis given anticoagulants for portal vein thrombosis (PVT), compared to patients without cirrhosis given VKAs, researchers report in the July issue of Clinical Gastroenterology and Hepatology. However, this risk is offset by the ability of VKA to increase portal

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  • Why is Gallbladder Cancer Mortality Decreasing in Some Countries but Increasing in Others?

Why is Gallbladder Cancer Mortality Decreasing in Some Countries but Increasing in Others?

Deaths from gallbladder and other biliary tract cancers are decreasing in most countries, but increasing in some high-income countries following decades of decline, researchers report in the March issue of Clinical Gastroenterology and Hepatology. These emerging trends may reflect lifestyle changes, such as increases in excess body weight. Gallbladder cancer is

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  • Which Patients Are at Greatest Risk From Mushroom Poisoning?

Which Patients Are at Greatest Risk From Mushroom Poisoning?

Almost 20% of patients with liver damage from mushroom (Amanita) poisoning and peak levels of total bilirubin greater than 2 mg/dL require liver transplantation or die, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The authors show that peak level of aspartate aminotransferase (AST) below 4000 IU/L identifies

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  • What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

Infections are frequent in patients with severe alcoholic liver disease, but are only independently associated with mortality when patients receive prednisolone, researchers report in the April issue of Gastroenterology. This could offset prednisolone’s therapeutic benefit. This study’s senior author, Mark Thursz, discusses the findings in a video abstract. As with

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  • Do Nonselective Beta Blockers Increase Mortality in Patients With Cirrhosis and Ascites?

Do Nonselective Beta Blockers Increase Mortality in Patients With Cirrhosis and Ascites?

Nonselective beta blockers (NSBBs) do not significantly increase the risk of death in patients with cirrhosis and ascites or refractory ascites, researchers report in the August issue of Clinical Gastroenterology and Hepatology. The findings from this meta-analysis do not support the position that NSBBs be routinely withheld from patients with

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  • Study Estimates Medical Errors May Cause More Than 250,000 Deaths Each Year in the US

Study Estimates Medical Errors May Cause More Than 250,000 Deaths Each Year in the US

Medical error is the third leading cause of death in the United States, after heart disease and cancer, a study concluded. Analyzing medical death rate data over an 8 year period, Marin Makary and Michael Daniel (Johns Hopkins University [JHU]) estimated that more than 250,000 deaths/year are due to medical error

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  • Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Statin use after a diagnosis of esophageal adenocarcinoma, but not esophageal squamous cell carcinoma, reduces esophageal cancer–specific and all-cause mortality, researchers report in the April issue of Gastroenterology. Esophageal cancer is the fifth most common cause of cancer-related death in men and eighth most common cause in women, worldwide. Esophageal

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  • As Incidence and Deaths from Other Cancers Decrease, Liver Cancer Increases in US

As Incidence and Deaths from Other Cancers Decrease, Liver Cancer Increases in US

Deaths from almost all cancers in the United States decreased from 1975 to 2012—except for liver cancer. In the Annual Report to the Nation on the Status of Cancer, 1975–2012, published online by the National Cancer Institute, A. Blythe Ryerson et al report that the overall cancer death rates for

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