• Which Patients Are at Greatest Risk From Mushroom Poisoning?

Which Patients Are at Greatest Risk From Mushroom Poisoning?

Almost 20% of patients with liver damage from mushroom (Amanita) poisoning and peak levels of total bilirubin greater than 2 mg/dL require liver transplantation or die, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The authors show that peak level of aspartate aminotransferase (AST) below 4000 IU/L identifies

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  • What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

Infections are frequent in patients with severe alcoholic liver disease, but are only independently associated with mortality when patients receive prednisolone, researchers report in the April issue of Gastroenterology. This could offset prednisolone’s therapeutic benefit. This study’s senior author, Mark Thursz, discusses the findings in a video abstract. As with

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  • Do Nonselective Beta Blockers Increase Mortality in Patients With Cirrhosis and Ascites?

Do Nonselective Beta Blockers Increase Mortality in Patients With Cirrhosis and Ascites?

Nonselective beta blockers (NSBBs) do not significantly increase the risk of death in patients with cirrhosis and ascites or refractory ascites, researchers report in the August issue of Clinical Gastroenterology and Hepatology. The findings from this meta-analysis do not support the position that NSBBs be routinely withheld from patients with

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  • Study Estimates Medical Errors May Cause More Than 250,000 Deaths Each Year in the US

Study Estimates Medical Errors May Cause More Than 250,000 Deaths Each Year in the US

Medical error is the third leading cause of death in the United States, after heart disease and cancer, a study concluded. Analyzing medical death rate data over an 8 year period, Marin Makary and Michael Daniel (Johns Hopkins University [JHU]) estimated that more than 250,000 deaths/year are due to medical error

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  • Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Statin use after a diagnosis of esophageal adenocarcinoma, but not esophageal squamous cell carcinoma, reduces esophageal cancer–specific and all-cause mortality, researchers report in the April issue of Gastroenterology. Esophageal cancer is the fifth most common cause of cancer-related death in men and eighth most common cause in women, worldwide. Esophageal

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  • As Incidence and Deaths from Other Cancers Decrease, Liver Cancer Increases in US

As Incidence and Deaths from Other Cancers Decrease, Liver Cancer Increases in US

Deaths from almost all cancers in the United States decreased from 1975 to 2012—except for liver cancer. In the Annual Report to the Nation on the Status of Cancer, 1975–2012, published online by the National Cancer Institute, A. Blythe Ryerson et al report that the overall cancer death rates for

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  • Almost 31,000 US Deaths Associated with Alcohol Use in 2014

Almost 31,000 US Deaths Associated with Alcohol Use in 2014

Americans are drinking themselves to death at a record-breaking rate, according a December 18 report from the Center for Disease Control and Prevention (CDC). In the Morbidity and Mortality Weekly Report, Rose A. Rudd et al reported that “30,700 Americans died from alcohol-induced causes, including alcohol poisoning and cirrhosis.” This

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  • Improving Outcomes of Patients With Fibrosing Cholestatic Hepatitis C

Improving Outcomes of Patients With Fibrosing Cholestatic Hepatitis C

Sofosbuvir-based regimens, with or without daclatasvir, greatly improve the clinical status of patients who develop fibrosing cholestatis hepatitis (FCH) after liver transplantation for hepatitis C virus (HCV) infection, and most of the patients achieve a sustained virologic response (SVR), researchers report in the November issue of Clinical Gastroenterology and Hepatology. These results

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  • Poor Adherence to Guidelines in Many Cases of Isoniazid-induced Liver Injury

Poor Adherence to Guidelines in Many Cases of Isoniazid-induced Liver Injury

Isoniazid is used to treat tuberculosis but is also a leading cause of liver injury. However, it is not clear how many cases of isoniazid-associated liver injury are reported or how many clinicians and patients adhere to American Thoracic Society (ATS) guidelines. In the September issue of Clinical Gastroenterology and Hepatology,

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Can We Treat Diarrhea by Stimulating Na+ Absorption?

Drugs designed to increase intestinal absorption of sodium might be the best approach for treatment of diarrheal diseases, according to the Advances in Translational Science article in the January issue of Clinical Gastroenterology and Hepatology. Acute diarrheal diseases are the second leading cause of of death in children under 5 years

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