• What are the Most Accurate Non-invasive Techniques for Measuring Liver Fibrosis and Steatosis?

What are the Most Accurate Non-invasive Techniques for Measuring Liver Fibrosis and Steatosis?

Magnetic resonance elastography (MRE) is more accurate than transient elastography (TE) in identifying liver fibrosis of stage 1 or more, researchers report in the February issue of Gastroenterology, using biopsy analysis as the standard. They also show that MRI-based proton density fat fraction (MRI-PDFF) analysis is more accurate than TE-based

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  • Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Can Disruption of the Intestinal Epithelial Barrier Contribute to Steatohepatitis?

Mice with defects in intestinal epithelial permeability develop more severe steatohepatitis when placed on a diet high in saturated fat, fructose, and cholesterol (HFCD) than control mice, and colon tissues from patients with non-alcoholic fatty liver disease (NAFLD) have similar defects in intestinal epithelial permeability, researchers report in the October

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  • How Could Variants in TM6SF2 Affect Risk for NAFLD?

How Could Variants in TM6SF2 Affect Risk for NAFLD?

The human transmembrane 6 superfamily member 2 (TM6SF2) protein regulates cholesterol metabolism in mice, researchers report in the May issue of Gastroenterology. These findings provide insight into the how a variant of TM6SF2 (encoding the amino acid change E167K) reduces total cholesterol and low-density lipoprotein cholesterol (LDL-c) levels in humans, and

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Advances in PSC, NAFLD, and Liver Transplantation for Patients with HCV Infection reported at International Liver Congress

A chemical cousin of an existing drug shows promise for patients with primary sclerosing cholangitis (PSC), a larger waistline increases risk for severe nonalcoholic fatty liver disease (NAFLD), and livers from hepatitis C virus (HCV)-infected donors are safe for transplant into HCV-infected recipients were all among the exciting findings reported

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  • Special Issue: Managing Patients With Liver Disease

Special Issue: Managing Patients With Liver Disease

A special issue of Clinical Gastroenterology and Hepatology is dedicated to the clinical management of hepatic disorders, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune hepatitis, and primary sclerosing cholangitis (PSC). The issue comprises 14 review articles that aim to present clinicians with evidence-based guidance and expert opinions on management of patients with liver

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  • What Causes Different Types of Fatty Liver Disease?

What Causes Different Types of Fatty Liver Disease?

Hepatic steatosis and steatohepatitis are increasing in prevalence, and can progress to histologically identical, more severe liver disease. They are associated with 3 main factors: alcohol, obesity or metabolic syndrome, and exposure to toxins. Researchers review the similarities, differences, and pathogenic mechanisms of alcohol-associated steatohepatitis (ASH), nonalcoholic steatohepatitis (NASH), and toxicant-associated fatty liver

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  • Does Weight Loss Resolve Fatty Liver Disease?

Does Weight Loss Resolve Fatty Liver Disease?

Two separate studies in the August issue of Gastroenterology show that weight loss, via diet or bariatric surgery, reduce features of non-alcoholic steatohepatitis (NASH). Eduardo Vilar-Gomez et al associated extent of weight loss, produced by lifestyle changes, with level of improvement in histologic features of NASH. The highest rates of NASH reduction

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  • A Quantitative Ultrasound Technology to Identify Patients with NAFLD and Quantify Steatohepatitis

A Quantitative Ultrasound Technology to Identify Patients with NAFLD and Quantify Steatohepatitis

A new quantitative ultrasound (QUS)  can accurately identify patients with non-alcoholic fatty liver disease (NAFLD) and quantify hepatic steatosis, researchers report in the July issue of Clinical Gastroenterology and Hepatology. With further validation, QUS could be an inexpensive, widely used technique to screen the general or at-risk population for NAFLD. The estimated prevalence of NAFLD

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  • Who is on the Liver Transplant Waitlist?

Who is on the Liver Transplant Waitlist?

The number of adults with nonalcoholic steatohepatitis (NASH) waiting for liver transplants has almost tripled in the last 10 years, researchers report in the March issue of Gastroenterology. NASH is now the second leading liver disease of adults awaiting liver transplantation in the United States, the researchers found. The prevalence of nonalcoholic fatty

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  • What are the Roles for Chemokines in Liver Disease?

What are the Roles for Chemokines in Liver Disease?

Sustained hepatic inflammation contributes to the progression of chronic liver diseases such as hepatitis C and non-alcoholic steatohepatitis. In the September issue of Gastroenterology, Fabio Marra and Frank Tacke review the roles of chemokines in liver inflammation and disease progression. In the liver, chemokines regulate the migration and activities of hepatocytes, Kupffer

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