• FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

The panoramic views obtained with full-spectrum endoscopy (FUSE) increase the number of dysplastic lesions detected in the colon, compared with conventional forward-viewing colonoscopy, researchers report in the May issue of Gastroenterology. Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy

Read more
  • Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Can Statin Use After Diagnosis of Esophageal Cancer Prolong Survival?

Statin use after a diagnosis of esophageal adenocarcinoma, but not esophageal squamous cell carcinoma, reduces esophageal cancer–specific and all-cause mortality, researchers report in the April issue of Gastroenterology. Esophageal cancer is the fifth most common cause of cancer-related death in men and eighth most common cause in women, worldwide. Esophageal

Read more
  • Who Should Undergo Surgery for Pancreatic Cysts?

Who Should Undergo Surgery for Pancreatic Cysts?

When should a patient with a pancreatic cystic lesion undergo surgery? How can we tell if the surgery will provide relief, or prevent death from pancreatic cancer, or burden a patient with an unnecessary procedure? Two articles in the October issue of Clinical Gastroenterology and Hepatology increase our understanding of

Read more
  • How to Get Rid of H pylori Infection—And do we Need to?

How to Get Rid of H pylori Infection—And do we Need to?

Helicobacter pylori infection increases risk of gastric cancer, by inducing inflammation and genetic instability in the gastric mucosa. However, it is not clear how best to clear the infection, or even whether H pylori can provide some health benefits. In a Review article in the April issue of Gastroenterology, David Y. Graham discusses the mechanisms H pylori–induced carcinogenesis and

Read more
  • Author Q&A Series: H pylori-associated Gastric Cancer

Author Q&A Series: H pylori-associated Gastric Cancer

Gastric tumors and tissues from humans and mice accumulate somatic mutations in various genes in the gastric mucosa upon Helicobacter pylori infection, researchers report in the August issue of Gastroenterology. In the study, Takahiro Shimizu et al. show that increased cytidine deaminase activity in these tissues promotes the accumulation of these mutations and might

Read more
  • Does Getting Rid of H pylori Stop Gastric Cancer’s Return?

Does Getting Rid of H pylori Stop Gastric Cancer’s Return?

Eradication of Helicobacter pylori after endoscopic resection of gastric lesions doesn’t prevent later development of new stomach tumors, researchers report in the May issue of Clinical Gastroenterology and Hepatology. H pylori infection can lead to gastric atrophy, intestinal metaplasia, and dysplasia or cancer—specifically non-cardia gastric cancer. It does so by inducing inflammation

Read more
  • Cancer Cells in Circulation

Cancer Cells in Circulation

Pancreatic cancer cells can be detected in patients’ circulation before tumors are discovered, researchers report in the March issue of Gastroenterology. Cancer cells have long been believed to acquire metastatic potential after large primary tumors are established. However, many patients undergoing pancreatectomy for chronic pancreatitis are found to have disseminated pancreatic

Read more
  • What are Choledochoceles?

What are Choledochoceles?

Choledochoceles are cystic dilatations of the intraduodenal portion of the common bile duct. They are often classified as Type III biliary cysts, but have distinct demographic and anatomic features, and a lower risk of malignancy than other types of choledochal cysts. In the February issue of Clinical Gastroenterology and Hepatology,

Read more

What is the Best Treatment for Esophageal Adenocarcioma?

Patients with esophageal adenocarcinoma (EAC) who receive endoscopic therapy survive as long as patients treated by surgery, according to the November issue of Clinical Gastroenterology and Hepatology. Esophageal cancer is a highly fatal malignancy—approximate 19% of patients survive 5 years. The incidence of EAC, the most common form of esophageal

Read more

What to do About Gastric Polyps

When clinicians detect a gastric polyp during endoscopy, they are faced with many questions: does the polyp need to be excised, or can a biopsy sample be collected and analyzed? Which polyps should be biopsied? Should patients then be followed, and how? In the November issue of Clinical Gastroenterology and

Read more