• Can THC Relieve Chronic Abdominal Pain?

Can THC Relieve Chronic Abdominal Pain?

In a phase 2 study, researchers found no difference between a delta-9-tetrahydrocannabinol (THC) tablet and a placebo tablet in reducing pain measures in patients with chronic abdominal pain from pancreatitis or surgery. Authors Marjan de Vries and Harry van Goor explain their findings in their video abstract: The study was

Read more
  • A Brain Enzyme That Controls Satiety

A Brain Enzyme That Controls Satiety

Researchers identified a brain enzyme that regulates how much food mice eat in one sitting—deletion of this enzyme caused the mice to increase their food intake to the point of becoming obese. The results could provide new therapeutic target for human obesity. To study brain mechanisms that control meal size

Read more
  • 5 Hospitalized and 1 Dead in Clinical Trial in France

5 Hospitalized and 1 Dead in Clinical Trial in France

Five men were hospitalized and 1 died after a drug trial in France, the country’s health minister announced on January 15. Marisol Touraine, the minister for social affairs, health, and women’s rights, said in a statement that her office was informed the evening of January 14 about a “serious accident”

Read more

A Rare, Autoimmune Cause of Intractable Nausea and Vomiting

Some cases of unexplained, intractable vomiting are caused by an autoimmune disorder in which patients develop antibodies against the brain protein astrocytic aquaporin-4 (AQP4), according to the March issue of Clinical Gastroenterology and Hepatology. AQP4 is a water channel in the central nervous system. Antibodies against AQP4 cause neuromyelitis optica

Read more

Molecular Mechanisms of Roux-en-Y Gastric Bypass

Many of the beneficial effects of Roux-en-Y gastric bypass (RYGB), including improved glucose homeostasis, require the actions of melanocortin-4 receptors (MC4Rs) on autonomic neurons, according to the March issue of Gastroenterology. Fasting glycemia often improves within days of RYGB (see below figure), which produces greater improvements in glucose homeostasis than

Read more

Treating Rumination and Supragastric Belching

Baclofen is an effective treatment for patients with rumination or supragastric belching/aerophagia, according to the April issue of Clinical Gastroenterology and Hepatology. Rumination syndrome is characterized by the effortless, often repetitive regurgitation of recently ingested food into the mouth; it results from contraction of the abdominal muscles and a subsequent

Read more