• A Brain Enzyme That Controls Satiety

A Brain Enzyme That Controls Satiety

Researchers identified a brain enzyme that regulates how much food mice eat in one sitting—deletion of this enzyme caused the mice to increase their food intake to the point of becoming obese. The results could provide new therapeutic target for human obesity. To study brain mechanisms that control meal size

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  • What Causes Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome?

What Causes Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome?

Colon tissues from patients with irritable bowel syndrome (IBS) produce increased levels of specific polyunsaturated fatty acid (PUFA) metabolites, which stimulate sensory neurons to generate visceral hypersensitivity. This occurs via activation of transient receptor potential (TRP) cation channels, researchers show in the August issue of Gastroenterology. IBS is characterized by abdominal

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Molecular Mechanisms of Roux-en-Y Gastric Bypass

Many of the beneficial effects of Roux-en-Y gastric bypass (RYGB), including improved glucose homeostasis, require the actions of melanocortin-4 receptors (MC4Rs) on autonomic neurons, according to the March issue of Gastroenterology. Fasting glycemia often improves within days of RYGB (see below figure), which produces greater improvements in glucose homeostasis than

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