How Can We Prevent Pancreatic Disease?

Tobacco use, obesity, and heavy use of alcohol are the factors most likely to increase risk for pancreatic diseases, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Vegetables and fruit, on the other hand, appear to reduce risk. Strategies to prevent acute pancreatitis, chronic pancreatitis, and pancreatic

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  • Can we Increase Detection of Duct Abnormalities by MRCP?

Can we Increase Detection of Duct Abnormalities by MRCP?

Administration of secretin improves noninvasive imaging of pancreatic duct abnormalities with higher levels of sensitivity than magnetic resonance cholangiopancreatography (MRCP), researchers report in the September issue of Gastroenterology. Pancreatic imaging is an essential element in evaluation of patients with abdominal pain or suspected pancreatitis. MRCP allows physicians to visualize fluid

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  • Can a Vaccine Prevent Pancreatic Cancer Progression?

Can a Vaccine Prevent Pancreatic Cancer Progression?

Researchers have developed immunotherapy to slow progression of early-stage pancreatic tumors in mice. This approach might be developed to prevent progression of premalignant lesions to PDA, researchers report in the June issue of Gastroenterology. Pancreatic ductal adenocarcinoma (PDA) is a difficult cancer to treat because it is usually detected at

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Preventing Hypoglycemia After Gastric Bypass

Many patients who undergo gastric bypass surgery experience hypoglycemia after meals. Researchers report in the March issue of Gastroenterology that they can correct this condition with an agent that blocks the receptor for the glucagon-like peptide 1 (GLP1). Roux-en-Y gastric bypass surgery, widely used to treat obesity, alters glucose metabolism in

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  • What are Choledochoceles?

What are Choledochoceles?

Choledochoceles are cystic dilatations of the intraduodenal portion of the common bile duct. They are often classified as Type III biliary cysts, but have distinct demographic and anatomic features, and a lower risk of malignancy than other types of choledochal cysts. In the February issue of Clinical Gastroenterology and Hepatology,

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A New Way to Detect Pancreatic Tumors?

Researchers have developed an ultrasound technique to image pancreatic tumors in mice, described in the October issue of Gastroenterology. This approach might useful in early detection of pancreatic ductal adenocarcinoma (PDAC). PDAC is the fourth leading cause of cancer death in the United States. It is usually diagnosed at an

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A Special Issue: the Exocrine Pancreas and its Disorders

Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic studies are being developed into new treatment strategies. To update

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What Causes Pancreatitis?

Trypsinogen might not be the sole culprit in acute pancreatitis, contradicting a century-old model of this disease; a new model is published in the December issue of Gastroenterology. Trypsinogen is a pancreatic protein that is converted in acinar cells to the enzyme trypsin—a protease that is important for digestion and

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Do Stents Prevent Pancreatitis After ERCP?

Pancreatic duct stents reduce the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), according to a study published in the October issue of Clinical Gastroenterology and Hepatology. Pancreatitis is the most common and potentially serious complication following ERCP, occurring in up to 9% of patients that receive this procedure and

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Dangerous Diabetes Drugs?

The drugs sitagliptin and exenatide, used to treat patients with type 2 diabetes, increase risk for pancreatitis and cancer, according to a study from Michael Elashoff and colleagues published in the July issue of Gastroenterology. The authors examined the United States (US) Food and Drug Administration’s database of reported adverse

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