• Distinguishing a Pancreatic Pseudocyst from a Mucinous Cystic Neoplasm

Distinguishing a Pancreatic Pseudocyst from a Mucinous Cystic Neoplasm

Researchers describe the case of a patient with what appeared to be a pancreatic pseudocyst that was found to be a benign mucinous cystic neoplasm (MCN), based on analysis of a cyst wall biopsy. In the March issue of Gastroenterology, Katie Connor et al  describe a 22-year-old woman who came

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Pancreaticobiliary Maljunction and Neuroendocrine Carcinoma

Researchers describe an unusual case—a patient with a neuroendocrine carcinoma of the gallbladder accompanied by pancreaticobiliary maljunction—in the March issue of Clinical Gastroenterology and Hepatology. Tomonori Matsumoto et al examined a 58-year-old man with epigastric pain. Computed tomography (A) and fluoro-2-deoxy-d-glucose positron emission tomography (B) revealed angular diffuse thickening of the gallbladder

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  • Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

An orally administered yeast lipase increases digestion of fat in a minipig model of pancreatic exocrine insufficiency (PEI), similar to that of pancreatin used in pancreatic enzyme replacement therapy, researchers report in the December issue of Gastroenterology. Patients with PEI have decreased pancreatic secretion of digestive enzymes such as lipase. This

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  • Who Should Undergo Surgery for Pancreatic Cysts?

Who Should Undergo Surgery for Pancreatic Cysts?

When should a patient with a pancreatic cystic lesion undergo surgery? How can we tell if the surgery will provide relief, or prevent death from pancreatic cancer, or burden a patient with an unnecessary procedure? Two articles in the October issue of Clinical Gastroenterology and Hepatology increase our understanding of

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  • The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

Excessive alcohol consumption disrupts expression and localization of the cystic fibrosis transmembrane conductance regulator (CFTR), researchers report in the February issue of Gastroenterology. People with loss-of-function mutations in the CFTR develop cystic fibrosis and are at risk for pancreatitis—the finding that alcohol intake also alters this protein could provide insight

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How Can We Prevent Pancreatic Disease?

Tobacco use, obesity, and heavy use of alcohol are the factors most likely to increase risk for pancreatic diseases, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Vegetables and fruit, on the other hand, appear to reduce risk. Strategies to prevent acute pancreatitis, chronic pancreatitis, and pancreatic

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  • Can we Increase Detection of Duct Abnormalities by MRCP?

Can we Increase Detection of Duct Abnormalities by MRCP?

Administration of secretin improves noninvasive imaging of pancreatic duct abnormalities with higher levels of sensitivity than magnetic resonance cholangiopancreatography (MRCP), researchers report in the September issue of Gastroenterology. Pancreatic imaging is an essential element in evaluation of patients with abdominal pain or suspected pancreatitis. MRCP allows physicians to visualize fluid

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  • Can a Vaccine Prevent Pancreatic Cancer Progression?

Can a Vaccine Prevent Pancreatic Cancer Progression?

Researchers have developed immunotherapy to slow progression of early-stage pancreatic tumors in mice. This approach might be developed to prevent progression of premalignant lesions to PDA, researchers report in the June issue of Gastroenterology. Pancreatic ductal adenocarcinoma (PDA) is a difficult cancer to treat because it is usually detected at

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Preventing Hypoglycemia After Gastric Bypass

Many patients who undergo gastric bypass surgery experience hypoglycemia after meals. Researchers report in the March issue of Gastroenterology that they can correct this condition with an agent that blocks the receptor for the glucagon-like peptide 1 (GLP1). Roux-en-Y gastric bypass surgery, widely used to treat obesity, alters glucose metabolism in

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  • What are Choledochoceles?

What are Choledochoceles?

Choledochoceles are cystic dilatations of the intraduodenal portion of the common bile duct. They are often classified as Type III biliary cysts, but have distinct demographic and anatomic features, and a lower risk of malignancy than other types of choledochal cysts. In the February issue of Clinical Gastroenterology and Hepatology,

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