What Causes Pancreatitis?

Trypsinogen might not be the sole culprit in acute pancreatitis, contradicting a century-old model of this disease; a new model is published in the December issue of Gastroenterology. Trypsinogen is a pancreatic protein that is converted in acinar cells to the enzyme trypsin—a protease that is important for digestion and

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Do Stents Prevent Pancreatitis After ERCP?

Pancreatic duct stents reduce the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), according to a study published in the October issue of Clinical Gastroenterology and Hepatology. Pancreatitis is the most common and potentially serious complication following ERCP, occurring in up to 9% of patients that receive this procedure and

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Dangerous Diabetes Drugs?

The drugs sitagliptin and exenatide, used to treat patients with type 2 diabetes, increase risk for pancreatitis and cancer, according to a study from Michael Elashoff and colleagues published in the July issue of Gastroenterology. The authors examined the United States (US) Food and Drug Administration’s database of reported adverse

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Tracking Pancreatic Cancer Cells

Tumors spread to other parts of the body when cancer cells can escape into the bloodstream, although it is not exactly clear how they enter the circulation or decide where to form new tumors. Andrew Rhim and colleagues at the University of Pennsylvania have developed a technology to label tumor

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Which Patients with Cystic Fibrosis are at Greatest Risk for Pancreatitis?

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause well-known lung defects, but in the January issue of Gastroenterology, Chee Y. Ooi et al. describe specific CFTR genotypes that increase risk for pancreatitis. Most patients with cystic fibrosis that carry mutations that severely disrupt CFTR function have a pancreatic

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For Pancreatic Cysts—(Change in) Size Matters

The speed of cyst growth predicts whether branch duct intraductal papillary mucinous neoplasms (Br-IPMNs) will become malignant, according to a study by Mee Joo Kang et al. in the January issue of Clinical Gastroenterology and Hepatology. IPMN is a premalignant pancreatic lesion that progresses from adenoma to carcinoma; cysts are

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Controlling Pancreatitis Pain

In patients with pancreatitis, treatments for the nervous system, rather than the pancreas itself, might better reduce pain, according to a study in the August issue of Clinical Gastroenterology and Hepatology. Chronic pancreatitis is painful—surgery or endoscopy to reduce pressure in the parenchyma or in the pancreatic duct does not

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