How Can We Screen for Pancreatic Cancer and its Precursors?

Individuals with invasive pancreatic cancer or high-grade dysplasia can be identified based on a specific DNA mutation in pancreatic juice samples from the duodena, according to the June issue of Clinical Gastroenterology and Hepatology. Tests for mutant TP53 might be developed to improve the diagnosis of and screening for pancreatic cancer and its precursors.

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A Special Issue: the Exocrine Pancreas and its Disorders

Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic studies are being developed into new treatment strategies. To update

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Can We Increase the Sensitivity of Pancreatic Cancer Cells to Chemotherapeutics?

Researchers have identified small molecules that increase the ability of chemotherapeutic agents to kill pancreatic cancer cells and slow tumor growth in mice, according to the February issue of Gastroenterology. One way that chemotherapeutics such gemcitabine, 5-fluorouracil, and platinum-based compounds kill cancer cells is by causing tumor suppressor proteins to

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Can Imaging Identify the Most Dangerous Pancreatic Cystic Neoplasms?

Endoscopic ultrasound can be used to identify cystic neoplasms of the pancreas that are most likely to become malignant, according to the February issue of Clinical Gastroenterology and Hepatology. Mucus-producing cystic neoplasms of the pancreas, including intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), that have mural nodules

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