• Can THC Relieve Chronic Abdominal Pain?

Can THC Relieve Chronic Abdominal Pain?

In a phase 2 study, researchers found no difference between a delta-9-tetrahydrocannabinol (THC) tablet and a placebo tablet in reducing pain measures in patients with chronic abdominal pain from pancreatitis or surgery. Authors Marjan de Vries and Harry van Goor explain their findings in their video abstract: The study was

Read more
  • Can Your Diet Affect Your Risk for Gallstone-related Pancreatitis?

Can Your Diet Affect Your Risk for Gallstone-related Pancreatitis?

Consumption of red meat, saturated fat, and cholesterol increase risk for gallstone-related acute pancreatitis, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Dietary fiber protects against acute pancreatitis—related and unrelated to gallstones—whereas coffee protects against acute pancreatitis not associated with gallstones, the study of thousands of patients

Read more
  • How Does Cigarette Smoking Lead to Chronic Pancreatitis?

How Does Cigarette Smoking Lead to Chronic Pancreatitis?

Aryl hydrocarbons in cigarette smoke activate an immune response that promotes pancreatic fibrosis and contributes to pancreatitis, researchers report in the December issue of Gastroenterology. The authors show that constituents of tobacco smoke activate signaling via the aryl hydrocarbon receptor (AHR) to induce T-cell production of interleukin 22 (IL22), activating

Read more
  • Do NSAIDs Prevent PEP?

Do NSAIDs Prevent PEP?

Rectal indomethacin does not prevent pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), researchers report from a randomized controlled study published in the April issue of Gastroenterology. These findings contradict more than a decade of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of post-ERCP pancreatitis (PEP). Acute pancreatitis is the

Read more
  • Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

Can We Use a Yeast Lipase in Enzyme Replacement Therapy for Pancreatic Exocrine Insufficiency?

An orally administered yeast lipase increases digestion of fat in a minipig model of pancreatic exocrine insufficiency (PEI), similar to that of pancreatin used in pancreatic enzyme replacement therapy, researchers report in the December issue of Gastroenterology. Patients with PEI have decreased pancreatic secretion of digestive enzymes such as lipase. This

Read more
  • Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Endoscopic sphincterotomy (ES) provides no benefit to patients receiving self-expandable metallic stents (SEMS) for a biliary stricture caused by pancreatic cancer, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The randomized controlled trial showed that ES procedure did not affect number of adverse events, SEMS patency, or

Read more
  • The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

The Same Path to Pancreatitis From Alcohol Abuse or Cystic Fibrosis?

Excessive alcohol consumption disrupts expression and localization of the cystic fibrosis transmembrane conductance regulator (CFTR), researchers report in the February issue of Gastroenterology. People with loss-of-function mutations in the CFTR develop cystic fibrosis and are at risk for pancreatitis—the finding that alcohol intake also alters this protein could provide insight

Read more

How Can We Prevent Pancreatic Disease?

Tobacco use, obesity, and heavy use of alcohol are the factors most likely to increase risk for pancreatic diseases, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Vegetables and fruit, on the other hand, appear to reduce risk. Strategies to prevent acute pancreatitis, chronic pancreatitis, and pancreatic

Read more
  • Can we Increase Detection of Duct Abnormalities by MRCP?

Can we Increase Detection of Duct Abnormalities by MRCP?

Administration of secretin improves noninvasive imaging of pancreatic duct abnormalities with higher levels of sensitivity than magnetic resonance cholangiopancreatography (MRCP), researchers report in the September issue of Gastroenterology. Pancreatic imaging is an essential element in evaluation of patients with abdominal pain or suspected pancreatitis. MRCP allows physicians to visualize fluid

Read more
  • What are Choledochoceles?

What are Choledochoceles?

Choledochoceles are cystic dilatations of the intraduodenal portion of the common bile duct. They are often classified as Type III biliary cysts, but have distinct demographic and anatomic features, and a lower risk of malignancy than other types of choledochal cysts. In the February issue of Clinical Gastroenterology and Hepatology,

Read more