A Special Issue: the Exocrine Pancreas and its Disorders

Everything you ever wanted to know about the pancreas, its development and function, and the pathogenesis and treatment of its disorders are now covered in a special issue of Gastroenterology. Pancreatology is a rapidly developing field—recent findings from molecular and genetic studies are being developed into new treatment strategies. To update

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Can Antioxidants Reduce Pain from Chronic Pancreatitis?

A randomized, placebo-controlled trial published in the September issue of Gastroenterology found that antioxidants do not reduce pain or improve quality of life in patients with chronic pancreatitis—at least for middle-aged patients with alcohol- or smoking-related disease. Chronic pancreatitis is characterized by inflammation of the pancreas, with loss of normal

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What Causes Pancreatitis?

Trypsinogen might not be the sole culprit in acute pancreatitis, contradicting a century-old model of this disease; a new model is published in the December issue of Gastroenterology. Trypsinogen is a pancreatic protein that is converted in acinar cells to the enzyme trypsin—a protease that is important for digestion and

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Do Stents Prevent Pancreatitis After ERCP?

Pancreatic duct stents reduce the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), according to a study published in the October issue of Clinical Gastroenterology and Hepatology. Pancreatitis is the most common and potentially serious complication following ERCP, occurring in up to 9% of patients that receive this procedure and

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Fluid Resuscitation for Acute Pancreatitis—When and With What?

Patients that are given fluid resuscitation within 24 hours of developing acute pancreatitis are less likely to experience systemic inflammatory response (SIR) or organ failure, according to a study by Matthew G. Warndorf et al. in the August issue of Clinical Gastroenterology and Hepatology. Acute pancreatitis is an inflammatory process

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