• How Does Smoking Lead to Pancreatic Cancer?

How Does Smoking Lead to Pancreatic Cancer?

Nicotine promotes pancreatic carcinogenesis by disrupting signaling and transcriptional pathways to cause dedifferentiation of acinar cells, researchers report in the November issue of Gastroenterology. One fourth of all deaths from pancreatic ductal adenocarcinoma (PDAC) are associated with tobacco use, and heavy smoking increases risk for PDAC 6-fold. Although smokers develop PDAC

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  • Measuring MicroRNAs to Detect Pancreatic Cancer

Measuring MicroRNAs to Detect Pancreatic Cancer

Analysis of microRNAs improves cytologic analysis of pancreatic fine-needle aspirates, allowing for more accurate identification of patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the October issue of Clinical Gastroenterology and Hepatology. This improvement could reduce the number of diagnostic procedures required for patients with pancreatic masses. Endoscopic ultrasound–guided fine-needle

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  • Can a Vaccine Prevent Pancreatic Cancer Progression?

Can a Vaccine Prevent Pancreatic Cancer Progression?

Researchers have developed immunotherapy to slow progression of early-stage pancreatic tumors in mice. This approach might be developed to prevent progression of premalignant lesions to PDA, researchers report in the June issue of Gastroenterology. Pancreatic ductal adenocarcinoma (PDA) is a difficult cancer to treat because it is usually detected at

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How Does a High-Fat Diet Contribute to Pancreatic Cancer?

A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of COX2, which promotes pancreatic inflammation. Increased body mass index and

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