• What Causes Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome?

What Causes Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome?

Colon tissues from patients with irritable bowel syndrome (IBS) produce increased levels of specific polyunsaturated fatty acid (PUFA) metabolites, which stimulate sensory neurons to generate visceral hypersensitivity. This occurs via activation of transient receptor potential (TRP) cation channels, researchers show in the August issue of Gastroenterology. IBS is characterized by abdominal

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