How Does PSC Lead to IBD?

Many patients with primary sclerosing cholangitis (PSC) also have inflammatory bowel disease (IBD), which becomes more severe after liver transplantation, researchers report in the May issue of Clinical Gastroenterology and Hepatology. These patients might require special immunosuppressive regimens. PSC is a chronic, cholestatic liver disease that eventually leads to cirrhosis

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What is Intrahepatic Cholangiocarcinoma?

Researchers have found that intrahepatic cholangiocarcinomas (ICCs) are really 2 different groups of tumors, based on molecular and genetic analyses, reported in the April issue of Gastroenterology. These findings identify class-specific mechanisms of oncogenesis that could lead to new treatment approaches for this common liver cancer. Cholangiocarcinoma is the second most

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A Rare, Autoimmune Cause of Intractable Nausea and Vomiting

Some cases of unexplained, intractable vomiting are caused by an autoimmune disorder in which patients develop antibodies against the brain protein astrocytic aquaporin-4 (AQP4), according to the March issue of Clinical Gastroenterology and Hepatology. AQP4 is a water channel in the central nervous system. Antibodies against AQP4 cause neuromyelitis optica

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What Can We Learn from a Pig Model of FAP?

A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop dysplasias in the colon and rectum that develop to adenomatous

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Origins of Gastric Cancer

Gastric tumors can arise from a single mutation in a single stomach gland, according to Lydia Gutierrez-Gonzalez et al. in the April issue of Gastroenterology. To study how gastric dysplasias form and expand, Gutierrez-Gonzalez et al. analyzed 23 samples of gastric epithelium from patients who received surgery for gastric adenocarcinoma

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Which Roads Lead to NASH?

Which Roads Lead to NASH? The progressive liver disease nonalcoholic steatohepatitis (NASH) is mediated by an innate immune response in the liver that causes tissue damage and fibrosis. The innate immune system protects against invading pathogens, but it’s not clear how it becomes activated in livers of patients with NASH.

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