• Hemosuccus Pancreaticus Caused by a Pancreatic Tumor

Hemosuccus Pancreaticus Caused by a Pancreatic Tumor

Researchers describe a rare cause of hemosuccus pancreaticus in a patient with pancreatic cancer. The gastrointestinal bleeding was caused by erosion of pancreatic adenocarcinoma into the colon, they show in the April issue of Clinical Gastroenterology and Hepatology. Hemosuccus pancreaticus is defined as hemorrhage from the ampulla of Vater via the pancreatic

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  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

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  • A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

Researchers have developed mice that develop focal, resectable pancreatic tumors closely resembling human pancreatic ductal adenocarcinomas (PDACs) that can be used to test adjuvant therapies, according to new research in the August issue of Gastroenterology. The authors show that administration of gemcitabine after resection of the tumors activates natural killer (NK) cell-mediated

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  • Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

A special issue of Gastroenterology features 14 articles discussing the genetic factors that contribute to a range of gastrointestinal (GI),  hepatobiliary, and pancreatic diseases, and how this information can be used in diagnosis and treatment of patients. An introduction to the special issue explains the value of associating diseases with specific genetic variants, which can help

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  • Measuring MicroRNAs to Detect Pancreatic Cancer

Measuring MicroRNAs to Detect Pancreatic Cancer

Analysis of microRNAs improves cytologic analysis of pancreatic fine-needle aspirates, allowing for more accurate identification of patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the October issue of Clinical Gastroenterology and Hepatology. This improvement could reduce the number of diagnostic procedures required for patients with pancreatic masses. Endoscopic ultrasound–guided fine-needle

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