• Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Can Restricting Fructose Intake Reduce Fatty Liver Disease in Children?

Reducing dietary fructose for as little as 9 days decreases liver fat, visceral fat, and de novo lipogenesis and increases insulin sensitivity, secretion, and clearance in children with obesity and metabolic syndrome, researchers report in the September issue of Gastroenterology. These findings support efforts to reduce sugar consumption. Consumption of sugar

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  • How Much Do Antibiotics Increase Risk of Obesity in Young Children?

How Much Do Antibiotics Increase Risk of Obesity in Young Children?

Administration of 3 or more courses of antibiotics to children younger than 2 years greatly increases their risk for early childhood obesity, researchers report in the July issue of Gastroenterology. Antibiotics have been used to promote weight gain in the agricultural industry for decades. This effect is believed to be

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  • Dangers of Ingested Button Batteries

Dangers of Ingested Button Batteries

A clinical report raises awareness of the frequency of button battery ingestion by children and the importance of immediate removal of batteries lodged in the esophagus. In the September issue of Gastroenterology, Seung Han Kim et al describe the case of a 22-month-old child taken to the emergency room by

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  • Chronic use of Narcotics Among Children with IBD

Chronic use of Narcotics Among Children with IBD

Chronic use of narcotics is common among children with inflammatory bowel disease (IBD)—particularly among those with anxiety and depression, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Identifying and treating psychological disorders could reduce symptoms that lead to narcotic use and their complications in these patients. Narcotics are prescribed

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  • Leptin Mutation Causes Early-Onset Extreme Obesity

Leptin Mutation Causes Early-Onset Extreme Obesity

A mutation in the gene encoding the appetite-controlling hormone leptin (LEP) found to cause extreme obesity in a young child, researchers report. Martin Wabitsch et al describe insatiable appetite and early-onset extreme obesity in a 2-year old caused by a homozygous transversion in LEP.  The boy had a high serum

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  • Do Kids with Abdominal Pain Become Adults with Abdominal Pain?

Do Kids with Abdominal Pain Become Adults with Abdominal Pain?

A large proportion of children with functional abdominal pain still have frequent abdominal pain in adolescence and young adulthood, even though fewer than 1% have a gastrointestinal (GI) disease, researchers report in the December issue of Clinical Gastroenterology and Hepatology. Chronic or recurrent abdominal pain is common in childhood, affecting

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  • What are the Long-Term Effects of Gastrointestinal Infections During Childhood?

What are the Long-Term Effects of Gastrointestinal Infections During Childhood?

An analysis of children affected by a Salmonella enteritidis outbreak more than 20 years ago provides evidence that pathogen-induced gastroenteritis during childhood is a risk factor for irritable bowel syndrome (IBS) in adults. The findings from this long-term study are published in the July issue of Gastroenterology. Functional dyspepsia and IBS affect

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Does EGD Identify Causes of Abdominal Pain in Children?

Esophagogastroduodenoscopy (EGD) is a useful tool for the diagnosis of children with abdominal pain, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The procedure identified disorders for which medical therapy was effective in 67% of children. Chronic abdominal pain is the most common indication for EGD in children.

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Causes and Treatment of Very-Early Onset IBD

Many infants with inflammatory bowel disease (IBD) have genetic defects that disrupt IL-10 signaling, according to the August issue of Gastroenterology. However, these children can be successfully treated by allogeneic hematopoietic stem cell transplantation, researchers report. IBD develops mostly in adolescents and young adults, but can occur in very young

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Why are Some Immunized Children Still At Risk for HBV Infection?

Despite immunization, children born to mothers with replicating HBV (marked by hepatitis B e antigen, or HBeAg) are still at risk for infection, according to the April issue of Gastroenterology. Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There have been proposals to

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