• Review Article: What are Serrated Colorectal Polyps?

Review Article: What are Serrated Colorectal Polyps?

Serrated polyps comprise hyperplastic polyps, sessile serrated lesions (SSLs), and traditional serrated adenomas (TSAs). Approximately 25% of sporadic colorectal cancers (CRCs) arise from serrated precursor lesions, but there is confusion regarding their terminology, classification, and risk. A review article by Seth D. Crockett and Iris D. Nagtegaal in the October issue of Gastroenterology clarifies

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  • What Drugs Can Reduce Risk of Colorectal Cancer?

What Drugs Can Reduce Risk of Colorectal Cancer?

Use of phosphodiesterase 5 (PDE5) inhibitors (commonly used to treat erectile dysfunction) is associated with a 35% reduction in risk of colorectal cancer (CRC) among male patients with benign colorectal neoplasms, researchers report in the September issue of Gastroenterology. The decreased risk of CRC was associated with an increased cumulative dose

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  • Intestinal Microbes as Carcinogens

Intestinal Microbes as Carcinogens

Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.

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  • Video: EUS Detection of Early-stage Gastric Cancer in a Patient with FAP

Video: EUS Detection of Early-stage Gastric Cancer in a Patient with FAP

Endoscopic ultrasound (EUS) can detect early-stage gastric cancers developing beneath or within the mucosa that are not visualized by endoscopy in patients with familial adenomatous polyposis (FAP). Researchers report these findings along with a video in the August issue of Gastroenterology. FAP is a hereditary colorectal cancer syndrome characterized by colorectal polyps and colorectal cancer. Patients

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  • Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Slightly more than 50% of people with an inherited risk for colorectal cancer (CRC) agree to undergo screening for this cancer, and most prefer colonoscopy to colon capsule endoscopy—even though these are equally effective screening tools—researchers report in the December issue of Clinical Gastroenterology and Hepatology. Colonoscopy should therefore remain

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  • Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

Expert Panel Recommends Aspirin Therapy for Prevention of Colorectal Cancer

For the first time, an expert panel has recommended aspirin therapy to prevent not only heart attacks but also colorectal cancer. The guideline for those at high risk of heart disease, published September 14 in a draft report from the US Preventive Services Task Force is the first time a major

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  • Can Capsule Colonoscopy Accurately Detect Polyps and Adenomas?

Can Capsule Colonoscopy Accurately Detect Polyps and Adenomas?

In an average-risk screening population, capsule colonoscopy identified individuals with polyps and adenomas with high levels of specificity, researchers report in the May issue of Gastroenterology. This procedure might be useful for patients who cannot undergo colonoscopy or who had incomplete colonoscopies. Capsule endoscopy, which involves an ingestible pill-sized endoscope that

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  • What to do About Sessile Serrated Adenomas

What to do About Sessile Serrated Adenomas

Sessile serrated adenomas (SSAs), characterized by the saw-toothed appearance of the colonic crypts, form and progress to colorectal cancers (CRCs) via a different pathway than conventional adenomas and are thought to contribute to 20% to 35% of all cases of CRC. Although little is known about their pathogenesis, endoscopists must be aware of the unique features of SSAs to efficiently detect

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Video: New Tool Aids Determination of Colonoscopy Surveillance Intervals

With an increased emphasis on improving quality and decreasing costs, new tools are needed to improve adherence to evidence-based practices and guidelines in endoscopy. In a video abstract, Timothy D. Imler describes an automated system that uses natural language processing (NLP) and clinical decision support to facilitate determination of colonoscopy surveillance

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What to do About Gastric Polyps

When clinicians detect a gastric polyp during endoscopy, they are faced with many questions: does the polyp need to be excised, or can a biopsy sample be collected and analyzed? Which polyps should be biopsied? Should patients then be followed, and how? In the November issue of Clinical Gastroenterology and

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