• What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?

The most reliable factors associated with symptom recurrence after anti-reflux surgery for patients with gastroesophageal reflux disease (GERD) are a primary complaint of extraesophageal reflux symptoms and lack preoperative response to acid-suppression therapy, researchers report in the May issue of Clinical Gastroenterology and Hepatology. Approximately 10% of the US population has

Read more
  • Why do Pancreatic Tumor Cells Love the Liver?

Why do Pancreatic Tumor Cells Love the Liver?

Pancreatic ductal adenocarcinoma (PDAC) and its precursors secrete high levels of tissue inhibitor of metalloproteinases 1 (TIMP1) into the circulation, which activates hepatic stellate cells (HSCs) in liver. These cells help create a niche that promotes metastasis of pancreatic tumors to liver, researchers report in the November issue of Gastroenterology.

Read more
  • Biomarker of Early-stage Aggressive Colon Cancer

Biomarker of Early-stage Aggressive Colon Cancer

Lack of the biomarker CDX2 identifies a subgroup of patients with high-risk stage II colon cancer who appeared to benefit from adjuvant chemotherapy. These patients are usually treated with surgery alone. The findings come from a study published online January 21 in the New England Journal of Medicine. Piero Dalerba

Read more
  • Is Fecal Calprotectin a Good Marker of Crohn’s Disease Recurrence?

Is Fecal Calprotectin a Good Marker of Crohn’s Disease Recurrence?

The fecal concentration of calprotectin can be used to monitor for recurrence of Crohn’s disease, with a high enough negative predictive value that physicians can be confident they won’t miss patients with recurrent disease, researchers report in the May issue of Gastroenterology. Approximately 80% of patients with Crohn’s disease require surgery

Read more
  • Which Patients with Early-stage Ulcerative Colitis Have the Worst Prognoses?

Which Patients with Early-stage Ulcerative Colitis Have the Worst Prognoses?

It is a challenge to accurately identify patients with early-stage ulcerative colitis (UC) who are at highest risk for a poor outcome and therefore might require salvage therapy. In a Perspective article in the April issue of Clinical Gastroenterology and Hepatology, Walter Reinisch et al present prognostic factors for adults with newly

Read more

Does Mucosal Healing Determine Which Patients Will Recover From Ulcerative Colitis?

Lack of mucosal healing, based on endoscopic analysis, identifies patients with ulcerative colitis (UC) who are not likely to respond to corticosteroid therapy, according to Sandro Ardizzone et al. in the June issue of Clinical Gastroenterology and Hepatology. In a prospective study, Ardizzone et al. followed 157 patients with moderate

Read more