• What are the Different Types of Liver Cancer, and How do They Develop?

What are the Different Types of Liver Cancer, and How do They Develop?

A review article in the March issue of Gastroenterology discusses different hypotheses about the cells responsible for liver tumorigenesis. The article also reviews the different classes of liver tumors, based on the molecular features, and how these affect patient prognosis. Daniela Sia et al describe the distinct molecular and clinical features of hepatocellular

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  • What Controls Liver Size?

What Controls Liver Size?

Most people know that liver can regenerate, but how does it know when to stop growing? Liver size is, in part, regulated by the size of the circulating bile acid pool, controlled by fibroblast growth factor 19 (FGF19), researchers show in the September issue of Gastroenterology. The mammalian liver can

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  • VEGF Signaling Prevents Senescence in Colorectal Tumors

VEGF Signaling Prevents Senescence in Colorectal Tumors

Vascular endothelial growth factor receptor-2 (VEGFR2) signaling prevents senescence of colorectal cancer cells by inactivating p21, researchers report in the July issue of Gastroenterology. Inactivation of this pathway correlates with survival of patients treated with anti-VEGF cancer drug bevacizumab. VEGF, a growth factor that has been well studied for its

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Are Mitochondria Involved in Ulcerative Colitis?

Changes in mitochondrial DNA that increase levels of ATP in the intestinal mucosa protect mice from colitis, according to the November issue of Gastroenterology. Strategies to increase mitochondrial ATP production by intestinal epithelial cells might therefore be developed to treat patients with ulcerative colitis (UC). Characteristics of UC include reduced levels

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