• What can we do with Gastrointestinal Organoids?

What can we do with Gastrointestinal Organoids?

Researchers review the latest discoveries from studies of tissue-derived and pluripotent stem cell–derived intestinal, gastric, esophageal, liver, and pancreatic organoids in the May issue of Gastroenterology. Studies of organoids have provided valuable information about GI development, tissue homeostasis, and disease and might be used to develop personalized medicines. In vitro organoid cultures are

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  • What Controls Liver Size?

What Controls Liver Size?

Most people know that liver can regenerate, but how does it know when to stop growing? Liver size is, in part, regulated by the size of the circulating bile acid pool, controlled by fibroblast growth factor 19 (FGF19), researchers show in the September issue of Gastroenterology. The mammalian liver can

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  • How is Notch Activated in Intestinal Stem Cells?

How is Notch Activated in Intestinal Stem Cells?

The enzyme ADAM10 serves as a cellular scissors that clips and activates Notch in the intestine, required for subsequent cell lineage specification and intestinal stem cell survival, researchers report in the October issue of Gastroenterology. These Notch-activated stem cells appear to have a competitive advantage for replenishing the stem cell

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Transplanting Engineered Mucosal Tissue into the Esophagus

Researchers have engineered tissues from oral epithelial cells that can be transplanted into the esophagus and promote healing after tumors are removed. According to the September issue of Gastroenterology, sutureless, endoscopic transplantation of sheets of autologous oral mucosal epithelial cells safely and effectively promotes re-epithelialization of the esophagus after surgery.

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