• How Much Do Antibiotics Increase Risk of Obesity in Young Children?

How Much Do Antibiotics Increase Risk of Obesity in Young Children?

Administration of 3 or more courses of antibiotics to children younger than 2 years greatly increases their risk for early childhood obesity, researchers report in the July issue of Gastroenterology. Antibiotics have been used to promote weight gain in the agricultural industry for decades. This effect is believed to be

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  • Researchers Identify Individuals Resilient to Severe Mendelian Childhood Diseases

Researchers Identify Individuals Resilient to Severe Mendelian Childhood Diseases

A genomic analysis of more than half a million people identified 13 individuals who appear to remain healthy despite carrying genetic mutations linked to severe childhood diseases. Although the biological reasons for this resilience are not yet understood, the study provides a first step toward identification of genetic variants that

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How Good Gut Microbes Resist Inflammation

Gut commensal bacteria survive inflammation by making a simple switch to their protective coats, researchers show. When harmful microbes like salmonella infect the gut, the innate immune system produces antimicrobial peptides to kill them. But these pathogenic microbes are often similar to the commensal microbes that live in the gut—it was

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Podcast: Efficacy of Vedolizumab in Patients with Moderately to Severely Active Crohn’s disease

Listen to Bruce Sands discuss his article in the September issue of Gastroenterology discussing results from placebo-controlled, phase 3 double-blind trial of the efficacy of vedolizumab  in patients with moderately to severely active Crohn’s disease, including those for whom previous anti-TNF treatment had failed. Sands et al. report that vedolizumab, an antibody against the integrin α4β7, is no more effective

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