• Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Can Exposure to Aflatoxin Cause Gallbladder Cancer?

Exposure to aflatoxin increases risk of gallbladder cancer, researchers report in the September issue of Gastroenterology. Ingestion of aflatoxin, produced by a fungi that grows on corn and peanuts, could account for the high incidence of gallbladder cancers in some regions of China and Chile. Gallbladder cancer, the most common biliary tract cancer, has

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  • Can Your Diet Affect Your Risk for Gallstone-related Pancreatitis?

Can Your Diet Affect Your Risk for Gallstone-related Pancreatitis?

Consumption of red meat, saturated fat, and cholesterol increase risk for gallstone-related acute pancreatitis, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Dietary fiber protects against acute pancreatitis—related and unrelated to gallstones—whereas coffee protects against acute pancreatitis not associated with gallstones, the study of thousands of patients

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  • Can we Identify People With IBD Before Symptoms Develop?

Can we Identify People With IBD Before Symptoms Develop?

People have high plasma levels of interleukin-6 (IL6) and c-reactive protein years before they are diagnosed with inflammatory bowel diseases (IBD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. These markers of systemic inflammation could be features of early-stage disease used to identify patients at risk. Crohn’s

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  • Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

Does a PNPLA3 Polymorphism Promote Fibrosis Progression in Patients with Hepatitis C?

A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3) is associated with baseline level of fibrosis and its progression, but not development of hepatocellular carcinoma (HCC), in patients with hepatitis C virus (HCV) infection, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Most

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  • What Loci Determine Susceptibility to IBD in African Americans?

What Loci Determine Susceptibility to IBD in African Americans?

Although many of the same genetic variants determine susceptibility to inflammatory bowel diseases (IBD) in Caucasians and African Americans, researchers report the identification of variants and loci not previously associated with IBD in African American populations. Analyses of these could provide insight into the pathogenesis of IBD, researchers state in

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  • Researchers Determine how FTO Variant Increases Obesity Risk

Researchers Determine how FTO Variant Increases Obesity Risk

Variants in the FTO gene have been associated with obesity and metabolic disease, but little is known about the function of its product. Researchers now show how this gene regulates body weight. FTO encodes a nuclear protein of the AlkB related non-heme iron and 2-oxoglutarate-dependent oxygenase superfamily. In the NIH

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  • Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Endoscopic sphincterotomy (ES) provides no benefit to patients receiving self-expandable metallic stents (SEMS) for a biliary stricture caused by pancreatic cancer, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The randomized controlled trial showed that ES procedure did not affect number of adverse events, SEMS patency, or

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  • New Approaches to IBS and IBD, But Concerns About PPIs, Highlighted at DDW

New Approaches to IBS and IBD, But Concerns About PPIs, Highlighted at DDW

A new test to identify diarrhea-predominant irritable bowel syndrome (D-IBS) and a new class of drugs to treat ulcerative colitis were presented at Digestive Disease Week (DDW) in Washington DC, May 15–19. Researchers also warned that many residents of nursing homes are being inappropriately given proton pump inhibitors (PPIs). Mark Pimentel

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Video Abstract: Increased Risk of Cervical Cancer in Women with IBD

Women with ulcerative colitis or Crohn’s disease are at increased risk for cervical neoplasias, researchers report in the April issue of Clinical Gastroenterology and Hepatology. Christine Rungoe et al performed a population-based cohort study of 27,408 women with inflammatory bowel diseases (IBD). In her video abstract, she says “we observed that women with ulcerative

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  • Veggie Diets, Especially With Fish, Cut Colorectal Cancer Risk

Veggie Diets, Especially With Fish, Cut Colorectal Cancer Risk

A vegetarian diet, especially one that includes fish, significantly reduces the risk of colorectal cancer, a large new study reports. These findings could lead to new strategies for cancer prevention. In the Adventist Health Study 2, researchers had 77,659 men and women from Seventh-day Adventist churches nationwide complete well-validated questionnaires

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