• What to do About Sessile Serrated Adenomas

What to do About Sessile Serrated Adenomas

Sessile serrated adenomas (SSAs), characterized by the saw-toothed appearance of the colonic crypts, form and progress to colorectal cancers (CRCs) via a different pathway than conventional adenomas and are thought to contribute to 20% to 35% of all cases of CRC. Although little is known about their pathogenesis, endoscopists must be aware of the unique features of SSAs to efficiently detect

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Stem Cells Account for Different Fates of Adenomatous and Hyperplastic Polyps

Adenomatous polyps expand the pool of colon stem cells to become malignant, whereas hyperplastic polyps (HPPs) do not, and therefore remain benign, according to a study published in the September issue of Gastroenterology. Many colorectal cancers arise from adenomatous polyps, which contain mutations that inactivate the tumor suppressor APC. These

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