• Can Direct-acting Antivirals Treatment of HCV Reactivate Herpesvirus Infection?

Can Direct-acting Antivirals Treatment of HCV Reactivate Herpesvirus Infection?

Researchers report reactivation of herpesvirus in 10 patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents in the November issue of Clincial Gastroenterology and Hepatology. Christie Perelló et al performed a case series analysis of reactivation of herpesvirus in patients with HCV infection treated with DAA

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  • Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?

Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?

In certain patients with hereditary hemochromatosis (HH), treatment with proton pump inhibitors (PPIs) for 2 or more years significantly reduced the number of phlebotomies required to maintain serum levels below 100 μg/L, researchers report in the January issue of Clinical Gastroenterology and Hepatology. HH is one of the most common

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  • Bradycardia After Sofosbuvir and Daclatasvir in 2 Patients Receiving Amiodarone

Bradycardia After Sofosbuvir and Daclatasvir in 2 Patients Receiving Amiodarone

Two patients receiving treatment with amiodarone developed bradycardia within 2 hours after taking sofosbuvir and daclatasvir  for hepatitis C, researchers report in the November issue of Gastroenterology. Patients treated with amiodarone should be continuously monitored within the first 48 hours after receiving these hepatitis C drugs, say the authors of the Brief Report. Sofosbuvir and

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  • Poor Adherence to Guidelines in Many Cases of Isoniazid-induced Liver Injury

Poor Adherence to Guidelines in Many Cases of Isoniazid-induced Liver Injury

Isoniazid is used to treat tuberculosis but is also a leading cause of liver injury. However, it is not clear how many cases of isoniazid-associated liver injury are reported or how many clinicians and patients adhere to American Thoracic Society (ATS) guidelines. In the September issue of Clinical Gastroenterology and Hepatology,

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  • Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Should Patients Undergo Endoscopic Sphincterotomy Before Receiving Self-expandable Metallic Stents?

Endoscopic sphincterotomy (ES) provides no benefit to patients receiving self-expandable metallic stents (SEMS) for a biliary stricture caused by pancreatic cancer, researchers report in the June issue of Clinical Gastroenterology and Hepatology. The randomized controlled trial showed that ES procedure did not affect number of adverse events, SEMS patency, or

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  • What’s Wrong With Herbal Supplements?

What’s Wrong With Herbal Supplements?

Herbal supplements, used by many people for weight loss and bodybuilding purposes but also to improve well-being and reduce symptoms of chronic diseases, have recently come under investigation because of uncertainty about their contents, safety, and efficacy. On February 3, the New York Times wrote that the New York State attorney general’s office accused 4 major retailers of selling

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  • Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Combined use of nonselective nonsteroidal anti-inflammatory drugs (nNSAIDs), COX-2 selective inhibitors, or low-dose aspirin with selective serotonin reuptake inhibitors significantly increases the risk of upper gastrointestinal (GI) bleeding, researchers report in the October issue of Gastroenterology. In their case series analysis of data from 114,835 patients with upper GI bleeding (930,888 person-years of follow-up),

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  • Linking Herbal Supplements with Liver Injury

Linking Herbal Supplements with Liver Injury

Despite the perceived safety of herbal and dietary supplements, they can cause serious liver injury. In the July issue of Clinical Gastroenterology and Hepatology, Simona Rossi and Victor J. Navarro discuss the scope, use, and regulation of herbal and dietary supplements, as well as the diagnosis of herbal and dietary

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Preventing Hypoglycemia After Gastric Bypass

Many patients who undergo gastric bypass surgery experience hypoglycemia after meals. Researchers report in the March issue of Gastroenterology that they can correct this condition with an agent that blocks the receptor for the glucagon-like peptide 1 (GLP1). Roux-en-Y gastric bypass surgery, widely used to treat obesity, alters glucose metabolism in

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How Often Do Medications Cause Liver Injury?

Drug-induced liver injury (DILI) could be more common than previously believed, according to a population-based study published in the June issue of Gastroenterology. Amoxicillin-clavulanate seems to be the most common cause, and azathioprine appears to be the most hepatotoxic. Many medications, such chlorpromazine, azathioprine, and sulfasalazine, can cause liver injury,

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