• Has MELD-Na Improved Outcomes of Patients on the Liver Transplant Waitlist?

Has MELD-Na Improved Outcomes of Patients on the Liver Transplant Waitlist?

Liver allocation based on model for end-stage liver disease-sodium (MELD-Na) score improved waitlist outcomes and provided significant benefit to patients with hyponatremia, researchers report in the November issue of Gastroenterology. However, there are discrepancies in transplantation survival benefit, so current rules for liver allocation might require revision, the authors state. The

Read more
  • An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

An Ex-vivo Model for Electrolyte Transport Along the Small Intestine

Undifferentiated or crypt-like, and differentiated or villus-like, human intestinal enteroids represent distinct points along the crypt–villus axis and can be used to characterize electrolyte transport processes along the small intestine, researchers report in the March issue of Gastroenterology. Studies of their duodenal enteroid model showed that electrogenic Na+/HCO3– cotransporter 1 in the

Read more

Can We Treat Diarrhea by Stimulating Na+ Absorption?

Drugs designed to increase intestinal absorption of sodium might be the best approach for treatment of diarrheal diseases, according to the Advances in Translational Science article in the January issue of Clinical Gastroenterology and Hepatology. Acute diarrheal diseases are the second leading cause of of death in children under 5 years

Read more