• A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

Endoscopic sleeve gastroplasty (ESG) delays gastric emptying, induces early satiation, and significantly reduces body weight, researchers report in the January issue of Clinical Gastroenterology and Hepatology. ESG could therefore be an alternative to bariatric surgery for some patients with obesity. Although bariatric surgery is the most effective therapy for obesity,

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  • A Twisted Stomach

A Twisted Stomach

Researchers report a case of gastric rotation, with inversion of the greater and lesser curvatures along the long axis of the stomach, in the May issue of Gastroenterology. Fady G. Haddad et al describe a 56-year-old woman with history of peptic ulcer disease, diverticulosis, hypertension, and hypothyroidism who presented with acute post-prandial epigastric pain.

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  • LARS vs PPIs for Treatment of GERD?

LARS vs PPIs for Treatment of GERD?

Patients receiving laparoscopic anti-reflux surgery (LARS) for chronic gastroesophageal reflux disease (GERD) had significantly greater long-term reductions in 24-hour esophageal acid exposure than patients given esomeprazole, researchers report in the May issue of Clinical Gastroenterology and Hepatology. However, both treatments controlled symptoms in most patients, and esophageal and gastric pH were not

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  • What can we do with Gastrointestinal Organoids?

What can we do with Gastrointestinal Organoids?

Researchers review the latest discoveries from studies of tissue-derived and pluripotent stem cell–derived intestinal, gastric, esophageal, liver, and pancreatic organoids in the May issue of Gastroenterology. Studies of organoids have provided valuable information about GI development, tissue homeostasis, and disease and might be used to develop personalized medicines. In vitro organoid cultures are

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  • Special Issue: Food, the Immune System, and the GI Tract

Special Issue: Food, the Immune System, and the GI Tract

The digestion of food and absorption of nutrients is the principal role of the gastrointestinal (GI) tract—everyone wants to know what we should eat and how it affects our body. Interactions between food and the immune system affect our microbiome, development of food allergies, nutrition, risk for inflammatory disorders or cancer, and even

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Video: Does Stress Cause Ulcers?

Psychological stress increases the risk for peptic ulcers, partly by affecting health risk behaviors, researchers report in the March issue of Clinical Gastroenterology and Hepatology. Although peptic ulcers are considered to be caused by stress, Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) took over as the accepted causes. However, less than a third of peptic ulcers develop in people

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  • Does Controlling Glycemia Increase Gastric Emptying in Patients with Diabetes?

Does Controlling Glycemia Increase Gastric Emptying in Patients with Diabetes?

Two-thirds of patients with poorly controlled type 2 diabetes have mostly asymptomatic yet abnormal gastric emptying, researchers report in the March issue of Clinical Gastroenterology and Hepatology. However, sustained improvements in glycemic control do not affect gastric emptying, the researchers found in a prospective study. Diabetes is associated with delayed

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In Vitro Stomach?

Researchers have developed an advanced, long-term, 3-dimensional organoid culture system for primary, untransformed human gastric epithelium. The system, described in the January issue of Gastroenterology, provides evidence for the presence of stem cells in adult human gastric tissue and can be used to study changes that occur in the gastric epithelium during

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  • Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Combined use of nonselective nonsteroidal anti-inflammatory drugs (nNSAIDs), COX-2 selective inhibitors, or low-dose aspirin with selective serotonin reuptake inhibitors significantly increases the risk of upper gastrointestinal (GI) bleeding, researchers report in the October issue of Gastroenterology. In their case series analysis of data from 114,835 patients with upper GI bleeding (930,888 person-years of follow-up),

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Video: Gastric to Esophageal Mucosal Transplantation

In the April issue of Gastroenterology, researchers report transplantation of mucosa from a patient’s stomach to esophagus, to prevent stricture formation after circumferential endoscopic mucosal dissection of early-stage esophageal cancer. Endoscopic submucosal resection and dissection are used to remove areas of dysplasia and cancer from the esophagus. However, stricture formation is a major drawback

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