• REVIEW: How Does Barrett’s Esophagus Develop?

REVIEW: How Does Barrett’s Esophagus Develop?

Mechanisms of Barrett’s esophagus (BE) pathogenesis are discussed in a review article by Jianwen Que et al in the August issue of Gastroenterology, including cell transdifferentiation and transcommitment. The authors discuss potential cells of origin for Barrett’s metaplasia, and the possibility that there could be more than 1 type of BE

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  • How Does Gastroparesis Vary Among Different People?

How Does Gastroparesis Vary Among Different People?

Gastroparesis causes, symptoms, and treatments vary among patients of different races, ethnicities, and sexes, researchers report in the July issue of Clinical Gastroenterology and Hepatology. The prevalence of some gastrointestinal (GI) disorders varies with race and ethnicity. For example, dyspepsia and irritable bowel syndrome are reported less frequently by African Americans.

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  • REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

CRISPR-Cas9 technology can be used to engineer organoids for studies of gastrointestinal development and disease pathogenesis. In the February issue of Gastroenterology, Masayuki Fujii et al review derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 has advanced studies of the digestive system. CRISPR-Cas9 genome editing technology allows researchers to

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  • What Endoscopic Techniques are Available for Weight Loss?

What Endoscopic Techniques are Available for Weight Loss?

Endoscopic techniques have been approved by the FDA for management of obesity, with many new devices and technologies in development. The pros and cons of these approaches, and the questions to be answered, are covered in a review article by Andrew C. Storm et al in the November issue of Clinical

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  • Dyspepsia and Hyperamylasemia Due to Plastic Spork Ingestion

Dyspepsia and Hyperamylasemia Due to Plastic Spork Ingestion

Researchers report a case of abdominal pain and hyperamylasemia due a duodenal foreign body in the September issue of Clinical Gastroenterology and Hepatology. Lotje Korteweg et al describe the case of a 38-year old man referred for endoscopic retrograde cholangiopancreatography. A gastroduodenoscopy had been performed for chronic dyspepsia and showed

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Gastroenterology Special Issue on Endoscopy

A special issue of Gastroenterology, Advances in Endoscopic Therapy, presents the latest advances in gastrointestinal endoscopy, including endoscopic images and videos. In their introductory article, Jacques J. Bergman and Patrick S. Yachimski explain that endoscopy is central to gastroenterology clinical practice and research, allowing examination of healthy and diseased tissue from the organ level, to the

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  • Review: Pathogenesis and Prevention of Gastric Cancer

Review: Pathogenesis and Prevention of Gastric Cancer

New diagnostic protocols, effective medical treatments, and recently developed conservative ablative procedures could make gastric cancer a preventable malignancy, says a review article in the December issue of Clinical Gastroenterology and Hepatology. Gastric cancer is 1 of the 5 most common causes of cancer death, and only 30% of patients survive 5

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  • Can Learning to Control Thoracic Muscle Activity Reduce Abdominal Distension?

Can Learning to Control Thoracic Muscle Activity Reduce Abdominal Distension?

A behavioral intervention designed to increase the postural tone of the abdomino-thoracic wall is effective treatment for abdominal distention of no detectable cause, researchers report in a randomized controlled trial published in the December issue of Clinical Gastroeneterology and Hepatology. Abdominal distension is one of the most common complaints among patients seeking

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  • Video: EUS Detection of Early-stage Gastric Cancer in a Patient with FAP

Video: EUS Detection of Early-stage Gastric Cancer in a Patient with FAP

Endoscopic ultrasound (EUS) can detect early-stage gastric cancers developing beneath or within the mucosa that are not visualized by endoscopy in patients with familial adenomatous polyposis (FAP). Researchers report these findings along with a video in the August issue of Gastroenterology. FAP is a hereditary colorectal cancer syndrome characterized by colorectal polyps and colorectal cancer. Patients

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Gastrointestinal Bleeding Caused by Gastric Tuberculosis

Researchers describe a case of gastric tuberculosis that led to GI bleeding in the June issue of Clinical Gastroenterology and Hepatology. Vishal Sharma et al report that a 30-year-old man who was a resident of North India presented to emergency services with 2 episodes of painless hematemesis. He did not have a history of

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