• Are Prebiotics or Diets Low in FODMAPs Better for Patients With Functional GI Disorders?

Are Prebiotics or Diets Low in FODMAPs Better for Patients With Functional GI Disorders?

Intermittent administration of prebiotics might be an alternative to dietary restrictions for patients with functional gut symptoms, researchers report in the October issue of Gastroenterology. A diet low in fermentable oligo-, di-, mono-saccharides and polyols (low-FODMAP diet) reduces symptoms of irritable bowel syndrome (IBS), and patients with gas-related symptoms can significantly

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  • What Are the Best Endpoints for Trials of Agents for Ulcerative Colitis?

What Are the Best Endpoints for Trials of Agents for Ulcerative Colitis?

Despite advances in methods of clinical trials for ulcerative colitis (UC), there is still a large amount of variation in endpoints, even in definitions of response and remission, reseachers found in a systematic review published in the May issue of Clinical Gastroenterology and Hepatology. The authors conclude that we need a

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  • What is the Best Way to Assess Treatment Response in Patients With Achalasia?

What is the Best Way to Assess Treatment Response in Patients With Achalasia?

A more accurate method to evaluate outcomes of treatment for achalasia is described in the May issue of Clinical Gastroenterology and Hepatology. The method identifies patients with good outcomes with higher levels of sensitivity (same specificity) than timed-barium esophagrams or impedance-manometry bolus transit assessments alone. Achalasia is an esophageal motor disorder

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  • Can Learning to Control Thoracic Muscle Activity Reduce Abdominal Distension?

Can Learning to Control Thoracic Muscle Activity Reduce Abdominal Distension?

A behavioral intervention designed to increase the postural tone of the abdomino-thoracic wall is effective treatment for abdominal distention of no detectable cause, researchers report in a randomized controlled trial published in the December issue of Clinical Gastroeneterology and Hepatology. Abdominal distension is one of the most common complaints among patients seeking

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  • What Happens to Patients With Markers of Celiac Disease but no Symptoms?

What Happens to Patients With Markers of Celiac Disease but no Symptoms?

A 3-year study of adults with potential celiac disease found most to have symptoms, and that these adults improve after gluten withdrawal, as reported in the May issue of Clinical Gastroenterology and Hepatology. The study also shows that patients without symptoms should not go on gluten-free diets, because they are unlikely

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  • Do Symptoms of Eosinophilic Esophagitis Indicate Disease Activity?

Do Symptoms of Eosinophilic Esophagitis Indicate Disease Activity?

Lack of symptoms of eosinophilic esophagitis (EoE) does not necessarily mean a lack of disease activity, researchers report in the March issue of Gastroenterology. They found only a moderate association between symptom scores and endoscopic or histologic features of remission. EoE is a chronic, immune- or antigen-mediated esophageal disease characterized

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  • What is the Best way to Manage Diverticulitis, and how Many People Have it?

What is the Best way to Manage Diverticulitis, and how Many People Have it?

Not all patients with multiple episodes of diverticulitis should undergo preventative surgery, shows a Markov decision model published in the January 2016 issue of Clinical Gastroenterology and Hepatology. Elective surgery after 2 episodes produces fewer quality-adjusted life-years (QALYs) than surgery after 3 episodes or conservative or medical treatments, the model found.

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Many Patients Without GERD Continue to Take PPIs

More than 42% of patients with negative results from pH monitoring studies continue proton pump inhibitor (PPI) therapy, despite evidence that they do not have gastroesophageal reflux disease (GERD), according to the June issue of Clinical Gastroenterology and Hepatology. PPI therapy is effective for about 75% of patients with GERD

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