• A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

Researchers have created nanoparticles that selectively kill hepatoma cells and reduce growth of liver tumors in rats, they report in the February issue of Gastroenterology. They show that the particles induce tumor-specific necrosis by selectively disrupting redox balance within cancer cells. Dietary intake of the natural omega-3 fatty acid docosahexaenoic

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  • Do Patients Continue Behavioral, Relaxation, and Dietary Strategies for IBS?

Do Patients Continue Behavioral, Relaxation, and Dietary Strategies for IBS?

A combination of cognitive behavioral therapy, relaxation, and dietary strategies reduced symptoms and increased quality of life in patients with irritable bowel syndrome (IBS), compared with usual care, researchers report in the February issue of Clinical Gastroenterology and Hepatology. The program produced sustainable behavioral changes in almost all participants after

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  • Is Combination Therapy Most Effective for HBV Infection?

Is Combination Therapy Most Effective for HBV Infection?

A significantly greater proportion of patients receiving a combination of tenofovir disoproxil fumarate (TDF) and pegylated interferon-α (peginterferon) for 48 weeks lost hepatitis B surface antigen (HBsAg), a marker of hepatitis B virus (HBV) DNA transcriptional activity, compared to patients given the standard care (peginterferon or TDF alone), researchers report

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New Treatment Approved by FDA for Lysosomal Acid Lipase Deficiency

The Food and Drug Administration (FDA) approved a drug called sebelipase alfa (Kanuma) as the first-ever treatment for lysosomal acid lipase deficiency (LAL)—a rare inherited disorder. LAL deficiency causes a build-up of fats within the cells of various tissues that can lead to liver and cardiovascular diseases and other complications.

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Should Patients with Crohn’s Disease Continue Receiving Immunomodulators When Starting Anti-TNF Therapy?

Continued use of immunomodulator therapy in patients with Crohn’s disease receiving anti-tumor necrosis factor (TNF) therapy is no more effective than anti-TNF monotherapy in inducing or maintaining response or remission, researchers show. The meta-analysis of randomized controlled trials is published in the December issue of Clinical Gastroenterology and Hepatology. There is debate

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  • Anemia—a Real Problem for Patients With IBD

Anemia—a Real Problem for Patients With IBD

Persistent or recurrent anemia is associated with severe and disabling inflammatory bowel disease (IBD), researchers report in the October issue of Clinical Gastroenterology and Hepatology. Persistent or recurrent anemia could be used as a marker of severe disease and to identify patients who require aggressive management. Anemia is a well-recognized but underestimated problem

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  • Public Health Officials Call for Wider Access to HCV Drugs

Public Health Officials Call for Wider Access to HCV Drugs

Experts from the Public Health Service and President Obama’s Advisory Council on HIV/AIDS are calling on federal and state Medicaid officials to widen access to prescription drugs that could cure tens of thousands of people with hepatitis C virus (HCV) infection. They say restrictions on the drugs imposed by many

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  • Can Curcumin Treat Mild-to-Moderate Ulcerative Colitis?

Can Curcumin Treat Mild-to-Moderate Ulcerative Colitis?

Addition of curcumin to mesalamine therapy increases its ability to induce clinical and endoscopic remission in patients with mild-to-moderate active ulcerative colitis (UC), researchers show in the August issue of Clinical Gastroenterology and Hepatology. Patients with mild-to-moderate UC are usually treated with oral and/or topical mesalamine. Those who do not

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Is Stretta an Effective Treatment for GERD?

An expensive radiofrequency ablation technique known as Stretta does not benefit patients with gastroesophageal reflux disease (GERD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. In a meta-analysis of randomized controlled studies, Seth Lipka et al found no evidence that Stretta normalized esophageal pH values, augmented lower esophageal

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  • What are the Effects of Antiviral Therapy in Patients With IBD and CMV Infection?

What are the Effects of Antiviral Therapy in Patients With IBD and CMV Infection?

Cytomegalovirus (CMV) infection complicates inflammatory bowel disease (IBD), but anti-viral therapy reduces the need for bowel surgery, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The benefits of anti-viral treatment are greatest for patients with high-grade disease, they show. CMV infection is more common in patients with

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