• Anemia—a Real Problem for Patients With IBD

Anemia—a Real Problem for Patients With IBD

Persistent or recurrent anemia is associated with severe and disabling inflammatory bowel disease (IBD), researchers report in the October issue of Clinical Gastroenterology and Hepatology. Persistent or recurrent anemia could be used as a marker of severe disease and to identify patients who require aggressive management. Anemia is a well-recognized but underestimated problem

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  • Public Health Officials Call for Wider Access to HCV Drugs

Public Health Officials Call for Wider Access to HCV Drugs

Experts from the Public Health Service and President Obama’s Advisory Council on HIV/AIDS are calling on federal and state Medicaid officials to widen access to prescription drugs that could cure tens of thousands of people with hepatitis C virus (HCV) infection. They say restrictions on the drugs imposed by many

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  • Can Curcumin Treat Mild-to-Moderate Ulcerative Colitis?

Can Curcumin Treat Mild-to-Moderate Ulcerative Colitis?

Addition of curcumin to mesalamine therapy increases its ability to induce clinical and endoscopic remission in patients with mild-to-moderate active ulcerative colitis (UC), researchers show in the August issue of Clinical Gastroenterology and Hepatology. Patients with mild-to-moderate UC are usually treated with oral and/or topical mesalamine. Those who do not

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Is Stretta an Effective Treatment for GERD?

An expensive radiofrequency ablation technique known as Stretta does not benefit patients with gastroesophageal reflux disease (GERD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. In a meta-analysis of randomized controlled studies, Seth Lipka et al found no evidence that Stretta normalized esophageal pH values, augmented lower esophageal

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  • What are the Effects of Antiviral Therapy in Patients With IBD and CMV Infection?

What are the Effects of Antiviral Therapy in Patients With IBD and CMV Infection?

Cytomegalovirus (CMV) infection complicates inflammatory bowel disease (IBD), but anti-viral therapy reduces the need for bowel surgery, researchers report in the May issue of Clinical Gastroenterology and Hepatology. The benefits of anti-viral treatment are greatest for patients with high-grade disease, they show. CMV infection is more common in patients with

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  • Do Selective Serotonin Reuptake Inhibitors Increase Risk for GI Bleeding?

Do Selective Serotonin Reuptake Inhibitors Increase Risk for GI Bleeding?

Use of selective serotonin reuptake inhibitors increases risk for upper gastrointestinal bleeding (UGIB) by 55%—and even more among patients also taking nonsteroidal anti-inflammatory or antiplatelet drugs, researchers report in the January issue of Clinical Gastroenterology and Hepatology. Risk might be reduced significantly by concomitant use of acid-suppressing drugs. Selective serotonin

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  • Is There a Treatment for Rumination Syndrome?

Is There a Treatment for Rumination Syndrome?

Rumination is an unperceived somatic response to food ingestion that disrupts abdominal accommodation, researchers report in the January issue of Clinical Gastroenterology and Hepatology. They go on to show that it can be corrected by biofeedback-guided control of abdomino-thoracic muscular activity. Rumination syndrome is characterized by effortless recurrent regurgitation of

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New Programs Track Off-Label Use of Targeted Cancer Drugs

Two programs are underway to track off-label use of targeted cancer drugs and patient outcomes, as well as facilitate patient access to these agents. According to Nature News, more than 60% of US prescriptions for cancer drugs are for off-label use—often because patients have a tumor with a feature or

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New Ways to Treat HCV Infection After Liver Transplant

New direct-acting agents against hepatitis C virus (HCV) can cure the infection when it recurs in patients with liver transplants. Researchers reported findings from 3 separate studies at the 65th Annual Meeting of the American Association for the Study of Liver Diseases last week in Boston. HCV is the leading

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  • Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Combined use of nonselective nonsteroidal anti-inflammatory drugs (nNSAIDs), COX-2 selective inhibitors, or low-dose aspirin with selective serotonin reuptake inhibitors significantly increases the risk of upper gastrointestinal (GI) bleeding, researchers report in the October issue of Gastroenterology. In their case series analysis of data from 114,835 patients with upper GI bleeding (930,888 person-years of follow-up),

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