• Is Gluten the Culprit in Non-Celiac Gluten Sensitivity?

Is Gluten the Culprit in Non-Celiac Gluten Sensitivity?

Rapidly fermented poorly absorbed short-chain carbohydrates, rather than gluten or other wheat proteins, might cause gastrointestinal symptoms in people who do not have celiac disease but feel better on gluten-free diets, according to the August issue of Gastroenterology. Individuals with non-celiac gluten sensitivity (NCGS), do not have celiac disease (based on

Read more

Are Patients Receiving the Latest Anti-HCV Drugs?

Less than 20% of patients infected with the most common Hepatitis C virus (HCV) genotype receive the latest drugs approved by the US Food and Drug Administration (FDA), according to the August issue of Clinical Gastroenterology and Hepatology. This low percentage could result from concerns of side effects or patient

Read more

Is SVR12 As Good As SVR24?

In patients with chronic Hepatitis C virus (HCV) infection, a sustained viral response to treatment regimens 12 weeks after therapy (SVR12) is a good indicator that the response will be maintained until week 24 (SVR 24), based on an analysis of pooled clinical trial data published in the June issue of

Read more

How Often Do Medications Cause Liver Injury?

Drug-induced liver injury (DILI) could be more common than previously believed, according to a population-based study published in the June issue of Gastroenterology. Amoxicillin-clavulanate seems to be the most common cause, and azathioprine appears to be the most hepatotoxic. Many medications, such chlorpromazine, azathioprine, and sulfasalazine, can cause liver injury,

Read more

Can Proton Pump Inhibitors Prevent Esophageal Cancer?

Proton-pump inhibitor (PPI) therapy reduces risk of esophageal cancer in patients with Barrett’s esophagus (BE), according to the April issue of Clinical Gastroenterology and Hepatology. In BE, the squamous epithelium of the distal esophagus is replaced by metaplastic columnar epithelium, as a result of chronic exposure to stomach acid. Patients

Read more

What are the Effects of Albumin in Patients With SBP?

Albumin infusion prevents renal impairment and reduces mortality among patients with spontaneous bacterial peritonitis (SBP), according to a meta-analysis published in the February issue of Clinical Gastroenterology and Hepatology. SBP is a common bacterial infection among cirrhotic patients and a dangerous complication of ascites. Mortality can reach 30% despite antibiotic

Read more

Can We Increase the Sensitivity of Pancreatic Cancer Cells to Chemotherapeutics?

Researchers have identified small molecules that increase the ability of chemotherapeutic agents to kill pancreatic cancer cells and slow tumor growth in mice, according to the February issue of Gastroenterology. One way that chemotherapeutics such gemcitabine, 5-fluorouracil, and platinum-based compounds kill cancer cells is by causing tumor suppressor proteins to

Read more

Stomach Botox for Weight Loss?

Gastric injections of botulinum toxin A (BTA) can delay gastric emptying but do not make obese individuals feel more full, alter their eating behaviors, or cause them to lose weight, according to the February issue of Clinical Gastroenterology and Hepatology. In attempts to help people lose weight, researchers have tested

Read more

Does a Response to Proton Pump Inhibitor Therapy Indicate GERD?

Just because a patient’s upper gastrointestinal symptoms are alleviated by proton pump inhibitors (PPIs) doesn’t necessarily mean that they have gastroesophageal reflux disease (GERD), according to the December issue of Clinical Gastroenterology and Hepatology. The efficacy of PPI therapy often is tested to determine whether patients’ symptoms are acid-related and

Read more

How do Intestinal Stem Cells get their Wnt?

Intestinal homeostasis and stem cells are not affected when Paneth cells stop producing Wnt, but Wnt is required to maintain the stem cell niche in intestinal epithelial cultures, according to a mouse study in the December issue of Gastroenterology. These findings indicate that underlying mesenchymal cells provide a secondary physiological

Read more