• Restoring Immune Regulation to Patients With Alcoholic Hepatitis

Restoring Immune Regulation to Patients With Alcoholic Hepatitis

Patients with alcoholic hepatitis have dysfunctional T-cell and natural killer cell responses that lead to overwhelming bacterial infections. Researchers report in the March issue of Gastroenterology that the immune impairment is mediated by endotoxin-induced over-expression of proteins called programmed cell death 1 (PD1) and mucin domain–containing protein 3 (TIM3), which suppress the immune

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Which Roads Lead to NASH?

Which Roads Lead to NASH? The progressive liver disease nonalcoholic steatohepatitis (NASH) is mediated by an innate immune response in the liver that causes tissue damage and fibrosis. The innate immune system protects against invading pathogens, but it’s not clear how it becomes activated in livers of patients with NASH.

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