• A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

A Minimally Invasive Endoscopic Procedure Instead of Bariatric Surgery?

Endoscopic sleeve gastroplasty (ESG) delays gastric emptying, induces early satiation, and significantly reduces body weight, researchers report in the January issue of Clinical Gastroenterology and Hepatology. ESG could therefore be an alternative to bariatric surgery for some patients with obesity. Although bariatric surgery is the most effective therapy for obesity,

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  • How Can We Study Genetic Heterogeneity Within Hepatocellular Carcinomas?

How Can We Study Genetic Heterogeneity Within Hepatocellular Carcinomas?

Researchers have developed a patient-derived cell line-based model to study how intratumor heterogeneity affects sensitivity of hepatocellular carcinoma (HCC) to different therapeutic agents, reported in the January issue of Gastroenterology. HCCs have a large amount of genetic heterogeneity within each tumor, making them difficult to treat. Multiple regions of tumors

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  • Can a Smartphone App Monitor IBD Activity?

Can a Smartphone App Monitor IBD Activity?

Researchers have developed a mobile health index for remote monitoring of patients with inflammatory bowel diseases (IBD) that could be incorporated into a smartphone app. These findings are reported in the December issue of Clinical Gastroenterology and Hepatology. The shift from symptom-oriented to prevention-oriented care delivery has accelerated the development of

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  • Can Yoga Reduce Symptoms of IBS?

Can Yoga Reduce Symptoms of IBS?

Yoga might be a feasible and safe adjunct treatment for irritable bowel syndrome (IBS), a systematic review shows in the December issue of Clinical Gastroenterology and Hepatology. The review found evidence for beneficial effects of yoga on gastrointestinal (GI) symptoms, quality of life, and anxiety, although further studies are needed. IBS is

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  • Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

Does Pancreatectomy With Islet Autotransplantation Benefit Patients With Recurrent Acute Pancreatitis?

In patients with recurrent acute pancreatitis, total pancreatectomy with islet autotransplantation (TPIAT) reduces pain and requirements for narcotic therapy, and increases quality of life, researchers report in the September issue of Clinical Gastroenterology and Hepatology. This treatment should be considered when medical and endoscopic therapies have failed. Recurrent acute pancreatitis, caused

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  • A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

A Mouse Model for Studying Pancreatic Tumor Resection and Adjuvant Therapy

Researchers have developed mice that develop focal, resectable pancreatic tumors closely resembling human pancreatic ductal adenocarcinomas (PDACs) that can be used to test adjuvant therapies, according to new research in the August issue of Gastroenterology. The authors show that administration of gemcitabine after resection of the tumors activates natural killer (NK) cell-mediated

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  • Long-term Efficacy of Octreotide in Patients with Polycystic Kidney and Liver Disease

Long-term Efficacy of Octreotide in Patients with Polycystic Kidney and Liver Disease

Three years of long-acting release octreotide (octreotide LAR) significantly reduced liver volume in patients with polycystic kidney and liver disease, researchers found in a placebo-controlled study. These reductions, reported in the July issue of Clinical Gastroenterology and Hepatology, were maintained for 2 years after treatment ended. Polycystic liver disease (PLD)

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DDW 2016: Stem Cells Help Heal Perianal Fistulas, Increasing Rates of Colorectal Cancer in Younger Individuals, and Agents Effective Against HCV Genotypes 1–6

Researchers reported important findings on a variety of gastrointestinal and hepatic disorders at Digestive Disease Week in San Diego. – A small, phase 1 study reported that a bioprosthesis plug soaked in autologous mesenchymal stem cells helped heal refractory perianal fistulas that commonly occur in patients with Crohn’s disease. Amy

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Advances in PSC, NAFLD, and Liver Transplantation for Patients with HCV Infection reported at International Liver Congress

A chemical cousin of an existing drug shows promise for patients with primary sclerosing cholangitis (PSC), a larger waistline increases risk for severe nonalcoholic fatty liver disease (NAFLD), and livers from hepatitis C virus (HCV)-infected donors are safe for transplant into HCV-infected recipients were all among the exciting findings reported

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  • What Happens to Patients With Markers of Celiac Disease but no Symptoms?

What Happens to Patients With Markers of Celiac Disease but no Symptoms?

A 3-year study of adults with potential celiac disease found most to have symptoms, and that these adults improve after gluten withdrawal, as reported in the May issue of Clinical Gastroenterology and Hepatology. The study also shows that patients without symptoms should not go on gluten-free diets, because they are unlikely

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