Advances in PSC, NAFLD, and Liver Transplantation for Patients with HCV Infection reported at International Liver Congress

A chemical cousin of an existing drug shows promise for patients with primary sclerosing cholangitis (PSC), a larger waistline increases risk for severe nonalcoholic fatty liver disease (NAFLD), and livers from hepatitis C virus (HCV)-infected donors are safe for transplant into HCV-infected recipients were all among the exciting findings reported

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  • What Happens to Patients With Markers of Celiac Disease but no Symptoms?

What Happens to Patients With Markers of Celiac Disease but no Symptoms?

A 3-year study of adults with potential celiac disease found most to have symptoms, and that these adults improve after gluten withdrawal, as reported in the May issue of Clinical Gastroenterology and Hepatology. The study also shows that patients without symptoms should not go on gluten-free diets, because they are unlikely

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  • Can Nutritional Therapy Help Patients with Minimal Hepatic Encephalopathy?

Can Nutritional Therapy Help Patients with Minimal Hepatic Encephalopathy?

Nutritional therapy for patients with cirrhosis and minimal hepatic encephalopathy (MHE) not only improves their nutritional status, but increases cognitive function, health-related quality of life (HRQOL), and liver function and reduces hospitalization, researchers report in the March issue of Clinical Gastroenterology and Hepatology. HE is a spectrum of neuropsychiatric abnormalities that develops in

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  • A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

Researchers have created nanoparticles that selectively kill hepatoma cells and reduce growth of liver tumors in rats, they report in the February issue of Gastroenterology. They show that the particles induce tumor-specific necrosis by selectively disrupting redox balance within cancer cells. Dietary intake of the natural omega-3 fatty acid docosahexaenoic

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  • Do Patients Continue Behavioral, Relaxation, and Dietary Strategies for IBS?

Do Patients Continue Behavioral, Relaxation, and Dietary Strategies for IBS?

A combination of cognitive behavioral therapy, relaxation, and dietary strategies reduced symptoms and increased quality of life in patients with irritable bowel syndrome (IBS), compared with usual care, researchers report in the February issue of Clinical Gastroenterology and Hepatology. The program produced sustainable behavioral changes in almost all participants after

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  • Can a Cocktail Prevent Colorectal Adenoma Recurrence?

Can a Cocktail Prevent Colorectal Adenoma Recurrence?

The combination of calcitriol, aspirin, and calcium carbonate did not prevent recurrence of colorectal adenomas over a 3-year period, found a prospective study published in the January issue of Gastroenterology. This negative result might have been affected by the numbers of smokers included in the study or low doses of

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  • Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?

Do Proton Pump Inhibitors Reduce the Need for Phlebotomy in Patients With Hereditary Hemochromatosis?

In certain patients with hereditary hemochromatosis (HH), treatment with proton pump inhibitors (PPIs) for 2 or more years significantly reduced the number of phlebotomies required to maintain serum levels below 100 μg/L, researchers report in the January issue of Clinical Gastroenterology and Hepatology. HH is one of the most common

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  • Is Combination Therapy Most Effective for HBV Infection?

Is Combination Therapy Most Effective for HBV Infection?

A significantly greater proportion of patients receiving a combination of tenofovir disoproxil fumarate (TDF) and pegylated interferon-α (peginterferon) for 48 weeks lost hepatitis B surface antigen (HBsAg), a marker of hepatitis B virus (HBV) DNA transcriptional activity, compared to patients given the standard care (peginterferon or TDF alone), researchers report

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  • Gilead Sells Sofosbuvir to Egypt for About $10 per Pill

Gilead Sells Sofosbuvir to Egypt for About $10 per Pill

In Egypt, pharmaceutical companies are testing a complicated deal to sell hepatitis C drugs at a fraction of their usual cost while imposing tight restrictions intended to protect lucrative markets in the West. According to the New York Times, Gilead Sciences Inc. is selling its sofosbuvir to the Egyptian government

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  • What is the Best way to Manage Diverticulitis, and how Many People Have it?

What is the Best way to Manage Diverticulitis, and how Many People Have it?

Not all patients with multiple episodes of diverticulitis should undergo preventative surgery, shows a Markov decision model published in the January 2016 issue of Clinical Gastroenterology and Hepatology. Elective surgery after 2 episodes produces fewer quality-adjusted life-years (QALYs) than surgery after 3 episodes or conservative or medical treatments, the model found.

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