• Should We Screen for HCC?

Should We Screen for HCC?

Screening patients with cirrhosis for hepatocellular carcinoma (HCC) by abdominal ultrasonography (USS) and/or measurement of serum level of alpha-fetoprotein (AFP) is not associated with reduced mortality from this cancer, reseachers report from a matched case–control study in the October issue of Gastroenterology. Patients with cirrhosis have a high risk (1%–8%

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  • Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Diets that promote intestinal inflammation can increase risk of colorectal carcinomas associated with specific bacteria in the microbiome, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Diet-induced intestinal inflammation alters the gut microbiome to contribute to colorectal cancer risk, which might be reduced with dietary changes. Chronic inflammation

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  • Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Patients are hyperglycemic for a mean period of 36 to 30 months before a diagnosis of pancreatic ductal adenocarcinoma (PDAC), researchers report in the August issue of Gastroenterology. This information might be used in strategies for early detection. At the time of PDAC diagnosis, approximately 85% of subjects have hyperglycemia

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  • A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

Researchers report a case of a patient with multiple adenomas and a family history of young-onset diabetes and hepatocellular carcinoma. They found these to be caused by a mutation in the HNF1 homeobox A gene (HNF1A), which caused maturity onset diabetes of the young type 3 (MODY3). Tom J. Harryvan et al evaluated a

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  • Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Drinking 2 or more cups of coffee per day after a diagnosis of stage I to III colorectal cancer (CRC) reduces risk of CRC-specific and all-cause mortality, researchers report in the March issue of Gastroenterology. Patients who maintain a high level of coffee consumption before and after diagnosis have even better odds for survival.

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  • Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Recently developed approaches for reshaping the pancreatic tumor stroma might be used in treatments for pancreatic cancer, according to a review in the March issue of Gastroenterology. The authors discuss relationships among the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and how these might be manipulated to stop pancreatic tumor

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  • Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Which Patients With Flat Low-grade Dysplasia are at High Risk for Colorectal Cancer?

Detection of flat low-grade dysplasia (fLGD) and aneuploidy in colon tissues increases risk for high-grade dysplaisa (HGD) or colorectal cancer (CRC) more than 5-fold in patients with inflammatory bowel disease (IBD), researchers report in the December issue of Gastroenterology. Aneuploidy was also detected in almost all cases of flat HGD (fHGD) IBD is a risk

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  • FISH and Mutations Best Identify Biliary Stricture Malignancies

FISH and Mutations Best Identify Biliary Stricture Malignancies

Addition of fluorescence in situ hybridization (FISH) and mutation analyses to cytology analysis significantly increases the sensitivity of detection of malignancies in biliary strictures, researchers report in the June issue of Clinical Gastroenterology and Hepatology. These techniques can be performed using standard brush samples collected during endoscopic retrograde cholangiopancreatography, with mutations detected in

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  • Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma

Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma

In a bioinformatic search for agents that alter the hepatocellular carcinoma (HCC)-specific gene expression pattern, researchers identified the anthelmintic drug niclosamide as a potential anti-tumor agent, described in the June issue of Gastroenterology. Niclosamide and its ethanolamine salt (NEN), with greater bioavailability, slowed growth of genetically induced liver tumors and

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  • FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

FUSE Outperforms Forward-viewing Colonoscopy in Detecting Dysplasia in Patients With IBD

The panoramic views obtained with full-spectrum endoscopy (FUSE) increase the number of dysplastic lesions detected in the colon, compared with conventional forward-viewing colonoscopy, researchers report in the May issue of Gastroenterology. Inflammatory bowel diseases (IBDs) increase the risk of colorectal cancer. Surveillance colonoscopy with chromoendoscopy is recommended, but conventional forward-viewing colonoscopy

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