• How Does Gastric Adenocarcinoma Develop?

How Does Gastric Adenocarcinoma Develop?

Overexpression of the peroxisome proliferator-activated receptor delta (PPARD) in gastric progenitor cells results in inflammation, dysplasia, and tumor formation in mice, researchers report in the July issue of Gastroenterology. Strategies to reduce PPARD in gastric progenitor cells might lead to treatments for stomach cancer. Gastric carcinogenesis is associated with chronic inflammation. The

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  • Are There Early Signs of Pancreatic Cancer?

Are There Early Signs of Pancreatic Cancer?

Changes in blood glucose and lipid levels occur up to 18 months before a diagnosis of pancreatic cancer, researchers report in the May issue of Gastroenterology. These changes might be used in combination with other risk factors to detect pancreatic cancer at earlier stages. One reason for the high mortality

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  • Can Surveillance be Extended or Eliminated for Some Patients With Barrett’s Esophagus?

Can Surveillance be Extended or Eliminated for Some Patients With Barrett’s Esophagus?

Two articles in the April issue of Clinical Gastroenterology and Hepatology show that surveillance intervals might be lengthened or even discontinued for subgroups of patients with Barrett’s esophagus. Stable non-dysplastic Barrett’s esophagus (NDBE) has a low risk of progression to high-grade dysplaisa (HGD) or esophageal adenocarcinoma (EAC), Yonne Peters et al

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  • Combined Genetic and Clinical Data Do Not Improve Determination of Risk for Esophageal Adenocarcinoma

Combined Genetic and Clinical Data Do Not Improve Determination of Risk for Esophageal Adenocarcinoma

Addition of genetic information to clinical factors does not increase identification of individuals at risk for esophageal adenocarcinoma, researchers report in the January 2019 issue of Gastroenterology. New screening and risk evaluation methods are needed to improve early detection of esophageal adenocarcinoma, because most patients receive a diagnosis at a late

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  • Should We Screen for HCC?

Should We Screen for HCC?

Screening patients with cirrhosis for hepatocellular carcinoma (HCC) by abdominal ultrasonography (USS) and/or measurement of serum level of alpha-fetoprotein (AFP) is not associated with reduced mortality from this cancer, reseachers report from a matched case–control study in the October issue of Gastroenterology. Patients with cirrhosis have a high risk (1%–8%

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  • Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Effects of Diet, Intestinal Inflammation, and the Microbiome on Risk of Colorectal Cancer

Diets that promote intestinal inflammation can increase risk of colorectal carcinomas associated with specific bacteria in the microbiome, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Diet-induced intestinal inflammation alters the gut microbiome to contribute to colorectal cancer risk, which might be reduced with dietary changes. Chronic inflammation

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  • Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Patients are hyperglycemic for a mean period of 36 to 30 months before a diagnosis of pancreatic ductal adenocarcinoma (PDAC), researchers report in the August issue of Gastroenterology. This information might be used in strategies for early detection. At the time of PDAC diagnosis, approximately 85% of subjects have hyperglycemia

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  • A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

A Genetic Cause for Multiple Adenomas and Diabetes in a Young Patient

Researchers report a case of a patient with multiple adenomas and a family history of young-onset diabetes and hepatocellular carcinoma. They found these to be caused by a mutation in the HNF1 homeobox A gene (HNF1A), which caused maturity onset diabetes of the young type 3 (MODY3). Tom J. Harryvan et al evaluated a

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  • Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Does Drinking Coffee Increase Survival of Patients With Colorectal Cancer?

Drinking 2 or more cups of coffee per day after a diagnosis of stage I to III colorectal cancer (CRC) reduces risk of CRC-specific and all-cause mortality, researchers report in the March issue of Gastroenterology. Patients who maintain a high level of coffee consumption before and after diagnosis have even better odds for survival.

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  • Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Review: How Does the Tumor Stroma Contribute to Pancreatic Cancer Progression, and Can We Stop It?

Recently developed approaches for reshaping the pancreatic tumor stroma might be used in treatments for pancreatic cancer, according to a review in the March issue of Gastroenterology. The authors discuss relationships among the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and how these might be manipulated to stop pancreatic tumor

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