• 3-D Imaging of T-cell Localization in Inflamed Colon Tissues

3-D Imaging of T-cell Localization in Inflamed Colon Tissues

Light sheet fluorescence microscopy (LSFM) provides accurate 3-dimensional images of inflammed intestine of mice with colitis, researchers show in a Gastroenterology in Motion article and video in the October issue of Gastroenterology. The authors demonstrate use of the technology to analyze migration of human T cells in colons of mice with colitis. Improved techniques are

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  • Does Consumption of Certain Fatty Acids Increase Risk of Ulcerative Colitis Flares?

Does Consumption of Certain Fatty Acids Increase Risk of Ulcerative Colitis Flares?

Diets with high levels of fatty acids such as myristic acid (found in palm oil, coconut oil, and dairy fats) increased risk of flare in patients with ulcerative colitis (UC), researchers report in the September issue of Clinical Gastroenterology and Hepatology. Their findings, from a prospective study of more than 400 patients

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  • Does Asthma Increase Risk for Inflammatory Bowel Diseases?

Does Asthma Increase Risk for Inflammatory Bowel Diseases?

A population-based case–control study published in the September issue of Clinical Gastroenterology and Hepatology associates asthma with later development of Crohn’s disease (CD) and with ulcerative colitis (UC). Although the etiology of asthma and inflammatory bowel diseases (IBD) are not well understood, they both involve complex interactions among genetic and environmental factors and the

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  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

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  • Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Can Vitamin D Affect Risk of Ulcerative Colitis Relapse?

Serum levels of vitamin D of 35 ng/mL or less in patients with ulcerative colitis (UC) in clinical remission are associated with disease relapse, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Increasing patients’ levels of vitamin D might reduce their risk for UC relapse. Vitamin D

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  • Is Dietary Fiber OK for Patients With Crohn’s Disease or Ulcerative Colitis?

Is Dietary Fiber OK for Patients With Crohn’s Disease or Ulcerative Colitis?

Intake of dietary fiber reduces risk of disease flares in patients with Crohn’s disease, but not ulcerative colitis, researchers report in the August issue of Clinical Gastroenterology and Hepatology. Recommendations to limit dietary fiber should therefore be re-evaluated. Inflammatory bowel diseases (IBD) have been associated with an abnormal mucosal immune response to

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  • Can we Identify People With IBD Before Symptoms Develop?

Can we Identify People With IBD Before Symptoms Develop?

People have high plasma levels of interleukin-6 (IL6) and c-reactive protein years before they are diagnosed with inflammatory bowel diseases (IBD), researchers report in the June issue of Clinical Gastroenterology and Hepatology. These markers of systemic inflammation could be features of early-stage disease used to identify patients at risk. Crohn’s

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  • Genetic Variants Associated with IBD Alter Immune Regulatory Signals from Beneficial Microbes

Genetic Variants Associated with IBD Alter Immune Regulatory Signals from Beneficial Microbes

Polymorphisms in susceptibility genes appear to promote development of inflammatory bowel diseases (IBD) by altering the abilities of immune cells to sense protective signals from the microbiome, researchers report. These findings help fill the missing link between genetic risk variants for IBD and dysbiosis of the intestinal microbiome. More than

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Does IBD Increase Risk for Oral Cancer?

Patients with inflammatory bowel diseases (IBD) have an increased risk of oral cancers—especially tongue cancer—researchers report in the March issue of Clinical Gastroenterology and Hepatology. Women are at higher risk than men. Oral cancers develop in the mucosal surfaces of the lips, floor of mouth, tongue, buccal mucosa, lower and

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  • What Loci Determine Susceptibility to IBD in African Americans?

What Loci Determine Susceptibility to IBD in African Americans?

Although many of the same genetic variants determine susceptibility to inflammatory bowel diseases (IBD) in Caucasians and African Americans, researchers report the identification of variants and loci not previously associated with IBD in African American populations. Analyses of these could provide insight into the pathogenesis of IBD, researchers state in

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